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Completed

NCT Number: NCT04867538

The Cholelithiasis in Adults With Short Bowel Syndrome

Short-term studies have shown that patients with short bowel syndrome (SBS) often develop cholestasis or cholelithiasis. In this retrospective cohort study, we aimed to define the incidence, risk factors, and clinical consequences of cholelithiasis in adults with SBS over an extended time period.

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Key information

Conditions

Short Bowel Syndrome Biliary Tract Diseases Cholelithiasis Digestive System Diseases Gastrointestinal Diseases Intestinal Diseases Malabsorption Syndromes Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

However, only limited data are available regarding cholelithiasis in patients with SBS. The prevalence of cholelithiasis in patients with SBS has been reported only in two studies. Furthermore, few studies have focused on identifying the risk factors for cholelithiasis in patients with SBS. Considering the marked improvements in medical care and nutrition support during the last 2 decades, the current incidence and risk factors for cholelithiasis in patients with SBS are unknown.

The aim of the current study was to provide comprehensive, longitudinal, and long-term data on the incidence of symptomatic and asymptomatic cholelithiasis in a cohort of patients with SBS, in order to identify the prevalence, risk factors, and clinical consequences of cholelithiasis in patients with SBS to aid in the development of protective interventions.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All eligible adults diagnosed with SBS

Exclusion criteria

age <18 years; history of cholelithiasis before SBS diagnosis; cholecystectomy; biliary tract obstruction or no abdominal imaging (CT, MRI, or ultrasound) after SBS diagnosis.

Treatment and study plan

No intervention

Other

No intervention

Primary outcomes

  1. the incidence of cholelithiasis in patients with SBS

    Time frame: 2010/1/1-2019/12/31

    the incidence of symptomatic and asymptomatic cholelithiasis in a cohort of patients with SBS

  2. risk factors

    Time frame: 2010/1/1-2019/12/31

    the risk factors of cholelithiasis in patients with SBS

  3. complications

    Time frame: 2010/1/1-2019/12/31

    the clinical consequences of cholelithiasis in patients with SBS

Sponsors and collaborators

Lead sponsor

Jinling Hospital, China

Other

Registry information

Official study title

Prevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome

Important dates

Study start
2010
Primary completion
2019
Study completion
2020
First posted
Apr 30, 2021
Registry last updated
Apr 30, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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