Specific Dietary Fibers May Enhance Colonic Adaptation in Short Bowel Syndrome Through Microbial and Metabolic Mechanisms That Drive Functional Compensation.

Ten patients with short intestines in clinical practice were intervened with dietary fiber. Serum and feces before and after the dietary fiber intervention were collected, and relevant indicators of nutrition and intestinal barrier were collected to observe the improvement of dietary fiber on patients with short intestines

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Short Bowel Syndrome Digestive System Diseases Gastrointestinal Diseases Intestinal Diseases Malabsorption Syndromes Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Eastern Theater Command General Hospital

Nanjing, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

All participants in Cohort 1 were recruited at the Eastern Theatre Command General Hospital (Nanjing, China) and provided written informed consent. The primary inclusion criterion was a confirmed diagnosis of type II or type III short bowel syndrome in patients aged 18

-70 years. Participants were excluded if they had other gastrointestinal diseases, malignant tumours, autoimmune diseases, infectious diseases or renal insufficiency (severe kidney disease with creatinine levels exceeding 3.0 mg/dL), or if they had taken antibiotics for more than three days within the preceding three months.

Treatment and study plan

Dietary fiber intervention

Dietary Supplement

Ten patients with short bowel syndrome in clinical practice were subjected to dietary fiber intervention. Blood and fecal samples were collected before and after the dietary fiber intervention, and nutritional and intestinal barrier-related indicators were also collected to observe the improvement effect of dietary fiber on these patients.

Primary outcomes

Determination of nitrogen content

Time frame: From enrollment to the end of treatment at 2 weeks

Sponsors and collaborators

Lead sponsor

Jinling Hospital, China

Other

Registry information

Official study title

Specific Dietary Fibers May Enhance Colonic Adaptation in Short Bowel Syndrome (SBS) Through Microbial and Metabolic Mechanisms That Drive Functional Compensation.

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Sep 22, 2025
Registry last updated: Sep 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed