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OpenTrials
Completed

NCT Number: NCT02928913

The Associations Between Sedentary Behaviour and Impact Characteristics on Bone Health

To investigate associations between sedentary and active behaviour with bone health and functional ability, and to associate mechanical loading at the lumbar spine and hip in sedentary and active individuals with bone mineral density.

Completed

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Key information

Age range

30 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Wolverhampton

Walsall, West Midlands, WS1 3BD, United Kingdom

About this study

Significant proportions of adults engage in sedentary behaviour for prolonged periods of time which is generally regarded as having deleterious effects on health. However, far less is known about its specific effects on bone health. Exercise has been proposed as a method of improving bone health, as impact forces generated as the foot contacts the ground during physical activity have the potential to aid bone maintenance and development.

The properties of bone are regulated through the amount mechanical loading, frequency of loading and duration of loading endured, which can create an osteogenic effect. These variables can be quantified via accelerometry which records the magnitude, rate and duration of accelerations experienced at the site on the body where the accelerometer is worn. Although there is a vast amount of literature where accelerometers have been used to monitor physical activity, there is a lack of studies that use accelerometers to determine the most effective exercise for bone, especially in relation to the lumbar spine. Exploring the bone health and loading characteristics of sedentary and low and highly active non-sedentary individuals will provide evidence upon which to base future interventions that are likely to be of benefit for bone health in sedentary populations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male or female aged 30 - 60 years Individuals who are sedentary and do not participate in physical activities Individuals who participate in some physical activities Individuals who are highly active Must be free from injury or illness that will affects following typical weekly routines.

Exclusion criteria

Any medical condition that affects bone health, e.g. osteoporosis. Currently takes medication that affects bone health, e.g. long term steroid use.

Inability to participate in typical daily activity, e.g. severe arthritis, injury. Women who are post menopause Women who are on hormone replacement therapy Unable to participate in DXA scan, e.g. due to recent exposure to radiation, pregnancy status.

Treatment and study plan

No intervention

Other

Primary outcomes

  1. Bone mineral density

    Time frame: One day

Secondary outcomes

  1. Mechanical loading dose during daily activity via accelerometry

    Time frame: 7 days

  2. Mechanical loading intensity during daily activity via accelerometry

    Time frame: 7 days

  3. Functional movement assessment: Grip Strength

    Time frame: One day

  4. Functional movement assessment: Timed up and go

    Time frame: One day

  5. Functional movement assessment: 10m walk test

    Time frame: One day

  6. Functional movement assessment: 5 times sit to stand

    Time frame: One day

  7. Functional movement assessment: gait analysis (acceleration at hip and lumbar spine)

    Time frame: One day

  8. Functional movement assessment: gait analysis (ground reaction force)

    Time frame: One day

Sponsors and collaborators

Lead sponsor

Dr Tina Smith

Other

Collaborators

  • London South Bank University

Registry information

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Oct 10, 2016
Registry last updated
Oct 26, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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