Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06341062

The Application of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU

The goal of this study is to quantitatively assess renal microcirculation changes by contrast-enhanced ultrasound and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore its predictive value in renal function recovery in patients with critical acute kidney injury. The main questions it aims to answer are:

1. To explore the quantitative parameters of contrast-enhanced ultrasound which can reflect the changes of renal microcirculation. 2. To explore the relationship between renal microcirculation and systemic hemodynamics. 3. To explore the value of renal microflow changes quantitatively evaluated by contrast-enhanced ultrasound in predicting renal function recovery.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Intensive Care Unit Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Ultrasound Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Ultrasound Diagnosis, Peking University Third Hospital

Beijing, Beijing Municipality, China

Location status: Recruiting

Location contact

Ligang Cui

CONTACT

[email protected]

13910627163

About this study

Quantitative analysis of cortical perfusion by contrast-enhanced ultrasound； Echocardiography； Quantitative results of renal artery and vein spectrum

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age >18 years old;
  • AKI was diagnosed < 24 hours after first admission to intensive care unit (ICU) and the expected length of stay in ICU ≥48 hours;
  • Meet Kidney Disease Improving Global Outcomes (KDIGO) 2012 diagnostic criteria for acute kidney injury;
  • Contrast-enhanced ultrasound was performed within 24 hours after diagnosis of acute kidney injury (AKI).

Exclusion criteria

  • Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysis treatment;
  • Kidney transplantation or renal malignancy;
  • Terminal stage of malignant tumor;
  • Pregnancy;
  • Renal artery stenosis or renal vein thrombosis;
  • Allergy to contrast agent SonoVue(BraccoSpA, Milan, Italy) or its components, or the presence of severe cardiopulmonary insufficiency (e.g., right-to-left shunt heart disease or pulmonary systolic blood pressure >90mmHg).

Treatment and study plan

Renal microcirculation quantitatively assessed by Contrast-enhanced ultrasound

Other

Renal microcirculation quantitatively assessed by Contrast-enhanced ultrasound before hospital discharge

Primary outcomes

  1. Serum creatinine values and/or urine output

    Time frame: Through study completion, an average of 7 days

    Complete recovery (defined as a return to normal serum creatinine and urine volume) and reversal of acute kidney injury (AKI) (more than 50% improvement in serum creatinine and/or urine volume from baseline), non-recovery included persistent AKI(no significant improvement or further increase in serum creatinine and/or urine volume, the need for dialysis, or death.)

Study contacts

Contact information is provided by the study sponsor or research team.

Ligang Cui, Dr

CONTACT

[email protected]

13910627163

Yuewei Zhang, Dr

CONTACT

[email protected]

18800109082

Sponsors and collaborators

Lead sponsor

Peking University Third Hospital

Other

Registry information

Official study title

The Application of Contrast-enhanced Ultrasound in Acute Kidney Injury in Intensive Care Unit

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
Apr 2, 2024
Registry last updated
Feb 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.