Department of Nutritional Sciences
Toronto, Ontario, M5S 3E2, Canada
NCT Number: NCT02619461
This study describes the effect of acute high intensity exercise at 70% VO2peak on inflammation, stress, appetite hormones and appetite in lean and obese children and adolescents.
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Notify Me10 year–18 year
Male
Interventional
Not applicable
Toronto, Ontario, M5S 3E2, Canada
In summary, exercise does induce a variety of metabolic mechanisms on a central and peripheral level, related to appetite other than solely gut peptides. The literature points towards a rather loose coupling when it comes to high intensity exercise and the suppression of food intake, without a clear explanation of the cause of exercise induced anorexia. This study is aimed to investigate high-intensity exercise and its effects on appetite and satiety hormones, inflammation, stress and eating behaviors on appetite and food intake.
The objective of the current study is to investigate the factors contributing to exercise-induced anorexia in lean and obese children, and maximize its translation into post-exercise suppression of food intake and promotion of negative energy balance particularly in obese children. It is hypothesized that high-intensity exercise would promote a greater suppression of food intake through suppression of appetite ratings via physiological mechanisms depending on stress and inflammation rather than gut peptides.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Exercise at 70%VO2max on a recumbent bicycle for 30 minutes to investigate the effects of exercise at high intensities on appetite and biomarkers of appetite and inflammation.
Time frame: Timeperiod of 2 hours during each study intervention.
Appetite will be assessed via visual analog scales. Each item will be scored from 0-100; 0 not hungry; 100 very hungry
Time frame: 4 timpoints during 2 hours during each study intervention.
Biomarkers of appetite will be assessed such as A. Ghrelin; GLP-1; PYY and Leptin
Time frame: 4 timpoints during 2 hours during each study intervention.
Biomarkers of inflammation will be assessed such as IL-6; IL-1beta; TNF-alpha; CRP
Time frame: 4 timpoints during 2 hours during each study intervention.
Biomarkers of stress will be assessed such as Cortisol and Adrenalin
University of Toronto
Other
The Acute Effect of High Intensity Exercise on Appetite, Appetite-regulating Hormones, and Bio-markers of Inflammation and Stress in Lean and Obese Boys
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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