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Completed

NCT Number: NCT02619461

The Acute Effect of Exercise on Appetite Appetite-regulating Hormones and Inflammation in Children

This study describes the effect of acute high intensity exercise at 70% VO2peak on inflammation, stress, appetite hormones and appetite in lean and obese children and adolescents.

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Key information

Age range

10 year–18 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Department of Nutritional Sciences

Toronto, Ontario, M5S 3E2, Canada

About this study

In summary, exercise does induce a variety of metabolic mechanisms on a central and peripheral level, related to appetite other than solely gut peptides. The literature points towards a rather loose coupling when it comes to high intensity exercise and the suppression of food intake, without a clear explanation of the cause of exercise induced anorexia. This study is aimed to investigate high-intensity exercise and its effects on appetite and satiety hormones, inflammation, stress and eating behaviors on appetite and food intake.

The objective of the current study is to investigate the factors contributing to exercise-induced anorexia in lean and obese children, and maximize its translation into post-exercise suppression of food intake and promotion of negative energy balance particularly in obese children. It is hypothesized that high-intensity exercise would promote a greater suppression of food intake through suppression of appetite ratings via physiological mechanisms depending on stress and inflammation rather than gut peptides.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 11 normal weight and 11 obese boys will be recruited for the study. Lean and obese boys aged 10-18 years, born full-term and with a normal body weight at birth, will be included in the study

Exclusion criteria

  • Dieters and individuals with lactose intolerance, allergies to milk and dairy products and gastrointestinal problems will be excluded from the study.

Treatment and study plan

Exercise

Other

Exercise at 70%VO2max on a recumbent bicycle for 30 minutes to investigate the effects of exercise at high intensities on appetite and biomarkers of appetite and inflammation.

Primary outcomes

  1. Appetite as assessed via visual analog scales

    Time frame: Timeperiod of 2 hours during each study intervention.

    Appetite will be assessed via visual analog scales. Each item will be scored from 0-100; 0 not hungry; 100 very hungry

  2. Biomarkers of appetite

    Time frame: 4 timpoints during 2 hours during each study intervention.

    Biomarkers of appetite will be assessed such as A. Ghrelin; GLP-1; PYY and Leptin

  3. Biomarkers of Inflammation

    Time frame: 4 timpoints during 2 hours during each study intervention.

    Biomarkers of inflammation will be assessed such as IL-6; IL-1beta; TNF-alpha; CRP

Secondary outcomes

  1. Biomarkers of Stress

    Time frame: 4 timpoints during 2 hours during each study intervention.

    Biomarkers of stress will be assessed such as Cortisol and Adrenalin

Sponsors and collaborators

Lead sponsor

University of Toronto

Other

Registry information

Official study title

The Acute Effect of High Intensity Exercise on Appetite, Appetite-regulating Hormones, and Bio-markers of Inflammation and Stress in Lean and Obese Boys

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Dec 2, 2015
Registry last updated
Dec 2, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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