TGFB1 And LAMA1 Gene Polymorphisms in High Myopia

The investigators aimed to investigate TGFB1 and LAMA1 gene polymorphisms in children with high myopia in order to determine the genetic basis of large myopic shifts causing severe visual impairment and complications.

Seventy-four children with high myopia (≥6 diopters [D]; study group) and 77 emmetropic children (±0.5D; control group) were included. Genetic and polymorphism analyses were performed in the Medical Genetics Laboratory using DNA purified from the patients' blood samples.

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Key information

Conditions

High Myopia Gene Mutations

Age range

3 year–13 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients under the age of 13
Patients with cycloplegic refraction values ≥6 D (for study group)
Emmetropic patients (for control group)

Exclusion criteria

Patients who had additional ocular pathology that may affect refraction (such as glaucoma, cataracts, corneal disease)
Patients with history of ocular surgery

Treatment and study plan

TGFB1 AND LAMA1 GENE POLYMORPHISMS

Genetic

we evaluated polymorphisms in the LAMA1 (rs2089760) and TGFB1 (rs4803455) genes in children younger than 13 years of age with ≥6 D myopia in an attempt to further elucidate the genetic basis of high myopia.

Primary outcomes

Genetic basis of high myopia

Time frame: 4 years

evaluated polymorphisms in the LAMA1 (rs2089760) and TGFB1 (rs4803455) genes in children younger than 13 years of age with ≥6 D myopia

Sponsors and collaborators

Lead sponsor

Ege University

Other

Registry information

Official study title

TGFB1 and LAMA1 Gene Polymorphisms in Turkish Children With High Myopia

Important dates

Study start: 2012
Primary completion: 2016
Study completion: 2017
First posted: Mar 2, 2018
Registry last updated: Mar 5, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed