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OpenTrials
Completed

NCT Number: NCT02205632

Relationships Between Macular Pigment Optical Density and Lacquer Cracks in High Myopic Patients.

Lutein ans zeaxanthin, carotenoids provided by dietary intake are mainly located in the macular area.

Its absorption peak at 460 nm may reduce photic damages. The macular pigment density can be evaluated by its optical density.

Reduced macular pigment level is a significant risk factor for age-macular degeneration. The nutritional intake can minimise the risk of age-macular degeneration.

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Key information

Conditions

High Myopia

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

ophthalmology department, Poitiers University Hospital

Poitiers, VIENNE, 86021, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age >18 years-old
  • High axial myopia < -6 dioptries
  • Presence or not of lacquer cracks in Bruch's membrane in one or both eyes
  • Patients with social security coverage

Exclusion criteria

  • Age <18 years-old
  • Amblyopia in the studied eye
  • Prior ocular surgery
  • Corneal disease or severe dry eye syndrome
  • Other retinal disease: diabetic retinopathy, age-related macular degeneration, macular hole, epiretinal membrane central
  • Extensive chorioretinal atrophy
  • Allergy to tropicamide
  • Pregnancy

Treatment and study plan

MPS II

Device

Primary outcomes

  1. Association between lacquer cracks related to high myopia and the macular pigment optical density

    Time frame: 1 day

Secondary outcomes

  1. The macular pigment optical density among high myopic patients

    Time frame: 1 day

Sponsors and collaborators

Lead sponsor

Poitiers University Hospital

Other

Registry information

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Jul 31, 2014
Registry last updated
Jun 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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