Active, Not Recruiting

NCT Number: NCT07195370

Testing YAG Laser Iridotomy for Primary Angle-Closure Glaucoma

This study evaluates the effectiveness and safety of YAG laser peripheral iridotomy performed at two different locations (temporal and inferior) in patients with primary angle-closure glaucoma, a leading cause of blindness worldwide. Patients visiting the glaucoma clinic at Feiz Hospital who are candidates for peripheral iridotomy will participate. In each patient, one eye will receive a temporal iridotomy, and the other eye will receive an inferior iridotomy, with patients unaware of the location used in each eye. The study will measure outcomes such as laser power, intraocular pressure, visual symptoms, and complications over six months to determine which approach is more effective and safer.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Glaucoma Eye Angle Closure Glaucoma Eye Diseases Glaucoma Glaucoma, Angle-Closure Ocular Hypertension

Age range

24 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Isfahan University of Medical Sciences

Isfahan, 0098, Iran

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of Primary Angle-Closure Glaucoma.

Adults (typically over 40 years old).

Ability to provide informed consent.

Narrow or closed anterior chamber angle (based on gonioscopy).

Intraocular pressure (IOP) controlled with medication but requiring surgery.

No previous iridotomy.

Exclusion criteria

econdary glaucoma.

Active eye diseases (e.g., infection or inflammation).

Advanced cataracts or lens-related issues.

Severe visual impairment (e.g., less than 20/200 vision).

Uncontrolled systemic diseases (e.g., diabetes or cardiovascular disease).

Pregnancy or breastfeeding.

Previous eye surgery (except for minor procedures).

Inability to follow-up with scheduled visits.

Treatment and study plan

peripheral iridotomy

Other

This procedure involves using a neodymium-doped yttrium aluminum garnet (YAG) laser to create a small hole in the temporal region of the iris in one eye. It aims to relieve intraocular pressure in patients with primary angle-closure glaucoma by improving the flow of aqueous humor. The procedure is performed under local anesthesia in a clinical setting, with patients unaware of which eye receives this treatment. Outcomes, including laser power, intraocular pressure, visual symptoms, and complications, are monitored over six months.

Primary outcomes

adverse events

Time frame: 1 day, 1 week, 1month

Surgical and postoperative complications (e.g., bleeding, infection, or changes in intraocular pressure).

Sponsors and collaborators

Lead sponsor

Isfahan University of Medical Sciences

Other

Registry information

Official study title

Evaluation of the Effectiveness of YAG Laser Iridotomy in Patients With Primary Angle-Closure: Temporal Peripheral Iridotomy Compared to Inferior Peripheral Iridotomy

Acronym: yag laser PI

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2026
First posted: Sep 26, 2025
Registry last updated: Sep 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Recruiting