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NCT Number: NCT05994209

Testing the Feasibility and Acceptability of Social Media and Digital Therapeutics to Decrease Vaping Behaviors

Use of vaping products (e.g., electronic nicotine delivery systems, e-cigarettes) has been increasing rapidly, particularly among teens and young adults. With limited information on the long-term effects of vaping products, health information about vaping has been somewhat unclear in regards to associated health risks. Teens and young adults may be reluctant to disclose their use of vaping products to parents or health providers and instead turn to social media to share and seek out information regarding vaping risks and cessation supports. Thus, our current proposal outlines the use of social media to identify teens and young adults socially networking about vaping, the use of an online chatbot screen to evaluate individual cessation support needs, and the use of a digital intervention system to support vaping cessation. The mobile intervention used in this study is based on a widely-used evidence-based mobile intervention for combustible smoking (i.e., quitSTART) and has been adapted for vaping and young adults to include an in-app chatbot to guide users to tailored content and to motivate and encourage their cessation efforts. We aim to integrate our social media recruitment and online screening approach to connect individuals with this mobile app intervention, and will conduct a randomized controlled trial to evaluate user engagement with and preliminary efficacy of the digital intervention on reducing vaping behaviors among teens and young adults.

Recruiting

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Key information

Age range

15 year–25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Washington University in St. Louis, School of Medicine

St Louis, Missouri, 63110, United States

Location status: Recruiting

Location contact

Erin Kasson

CONTACT

[email protected]

314-246-9156

Patricia Cavazos-Rehg, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • US Resident
  • English Speaking
  • Have daily access to a smartphone
  • Current vaping product user (P30D)
  • Identified as socially networking about a desire to quit vaping and/or experiencing negative health outcomes due to vaping
  • Vaping product user only (i.e., not using vaping as a means to support combustible smoking cessation)

Treatment and study plan

quitSTART Mobile Application

Device

Mobile application with educational content, motivational messages, self-monitoring, and tips for managing cravings to support vaping cessation among young adults.

Chatbot Feature in quitSTART Mobile Application

Behavioral

In-App chatbot feature emedded into quitSTART mobile application to motivate vaping cessation and support app navigation.

Primary outcomes

  1. Vaping cessation

    Time frame: Baseline, 6 weeks, 3 months

    Vaping cessation as assessed by 7 day self-reported vaping abstinence at follow-up. Timeline follow back procedures will be used to establish abstinence or if participants lapsed (their first instance of vaping post quit) or relapsed (vaped on 7 consecutive days) at each follow up time point.

Secondary outcomes

  1. Nicotine dependence

    Time frame: Baseline, 6 weeks, 3 months

    Nicotine dependence will be assessed using the 4-item Patient-Reported Outcomes Measurement Information System (PROMIS).

  2. Risk perception related to vaping

    Time frame: Baseline, 6 weeks, 3 months

    Perceived risks of vaping, both general and conditional, will be assessed with two items adapted from Wackowski et al., 2020. "How harmful, if at all, do you think vaping/using an e-cigarette is to a user's health?" (general) and "Imagine you vaped/used e-cigarettes daily for the next 10 years and used no other tobacco product. How harmful do you think this vaping would be to your health?" (conditional), both using a five-point response scale (not at all-extremely harmful).

  3. Intervention engagement

    Time frame: Baseline, 6 weeks, 3 months

    Data automatically captured within the chatbot, and app platform will be used to calculate a composite measure of engagement for those randomized to each of these intervention components and will be examined as a predictor of outcomes. We will use a modified version of an app Engagement Index (EI).

Study contacts

Contact information is provided by the study sponsor or research team.

Erin Kasson, MSW

CONTACT

[email protected]

314-362-9003

Patricia Cavazos-Rehg, PhD

CONTACT

[email protected]

314-362-2152

Sponsors and collaborators

Lead sponsor

Washington University School of Medicine

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)
  • The University of Texas Health Science Center, Houston
  • University of South Carolina

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Aug 16, 2023
Registry last updated
Apr 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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