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Enrolling by Invitation

NCT Number: NCT07365813

Testing Alcohol Cancer Risk Messages

Testing gain vs loss-framed messages to address drinking among cancer survivors

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Key information

Conditions

Alcohol Cancer Neoplasms

Age range

21 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Miami

Miami, Florida, 33136, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 21 years or older
  • Resident of the United States
  • Able to read and speak English
  • Diagnosed with one of the following cancers: mouth, throat, larynx, liver, colon, rectum, or breast
  • Current alcohol user (≥ 1 alcoholic drink in the past 30 days)

Exclusion criteria

  • Adults unable to consent
  • Individuals younger than 21
  • Not residing in the US
  • Non-alcohol users (<1 drink)
  • Less than 50% completion of the survey

Treatment and study plan

Text-only messages

Behavioral

The study will test eight alcohol-cancer risk messages (four gain-framed and four loss-framed). Each message will be developed at three intensity levels (text-only, neutral image, and graphic image), yielding 24 total message stimuli.

AI-developed Neutral pictorial messages

Behavioral

The study will test eight alcohol-cancer risk messages (four gain-framed and four loss-framed). Each message will be developed at three intensity levels (text-only, neutral image, and graphic image), yielding 24 total message stimuli.

AI-developed graphic pictorial messages

Behavioral

The study will test eight alcohol-cancer risk messages (four gain-framed and four loss-framed). Each message will be developed at three intensity levels (text-only, neutral image, and graphic image), yielding 24 total message stimuli.

Primary outcomes

  1. Change in alcohol-cancer harm perception

    Time frame: Within 15 minutes on a single online session - from before message exposure (pre-exposure) to after message exposure (post-exposure).

    Change in participants' beliefs about experiencing cancer in the future due to alcohol use measured on a scale from 1 (not at all) to 5 (a lot). The outcome is the change on the mean score from the pre to post exposure.

  2. Intention to Reduce Alcohol consumption

    Time frame: Within 15 minutes on a single online session - from before message exposure (pre-exposure) to after message exposure (post-exposure).

    Change in participants' intention to reduce alcohol consumption in the next month, measured on a scale from 1 (not at all) to 5 (a lot). The outcome is the change on the mean score from the pre to post exposure.

  3. Commitment to a limited drinking goal in the next month

    Time frame: Within 15 minutes on a single online session - from before message exposure (pre-exposure) to after message exposure (post-exposure).

    Change in participants' intention to commit to a drinking limit goal in the next month, measured on a scale from 1 (not at all) to 5 (a lot). The outcome is the change on the mean score from the pre to post exposure.

Secondary outcomes

  1. Message perceived effectiveness

    Time frame: One time (within 5 minutes) post-exposure evaluation.

    Self reported perceived overall effectiveness of the message measured on a scale from 1 (not at all) to 5 (a lot) scale. The outcome is the mean score.

  2. Message Receptivity

    Time frame: One time (within 5 minutes) post-exposure evaluation.

    Self reported message receptivity including attention, emotional reaction, believability, fear, relevance, anticipated social interactions, recall and avoidance on a scale from 1 (not at all) to 5 (a lot). The outcome is the composite mean score assessing attention, emotional reaction, believability, fear, relevance, anticipated social interactions, recall, avoidance, and perceived effectiveness. Higher scores indicate greater message receptivity.

Sponsors and collaborators

Lead sponsor

University of Miami

Other

Registry information

Official study title

Developing and Testing AI-Generated Messages on Alcohol and Cancer Risk: A Proof of Concept

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Jan 26, 2026
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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