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Active, Not Recruiting

NCT Number: NCT05179824

Tempus Priority Study: A Pan-tumor Observational Study

Observational study that will be collecting clinical and molecular health information from cancer patients who have received comprehensive genomic profiling and meet the specific eligibility criteria outlined for each cohort with the goal of conducting research to advance cancer care and create a dataset that furthers cancer research.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Breast Cancer Adnexal Diseases Bile Duct Diseases Bile Duct Neoplasms Biliary Tract Diseases Biliary Tract Neoplasms Bladder Cancer Bone Diseases Bone Neoplasms Brain Cancer Brain Diseases Brain Neoplasms Breast Diseases Breast Neoplasms Cancer of Bone and Connective Tissue Cancer of Cervix Cancer of Colon Cancer of Endometrium Cancer of Esophagus Cancer of Gastrointestinal Tract Cancer of Head and Neck Cancer of Kidney Cancer of Larynx Cancer of Liver Cancer of Rectum Cancer of Skin Cancer of Stomach Cancer of Vulva Cancer of the Bile Duct Central Nervous System Diseases Central Nervous System Neoplasms Colonic Diseases Colonic Neoplasms Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Endocrine Gland Neoplasms Endocrine System Diseases Endometrial Neoplasms Esophageal Diseases Esophageal Neoplasms Fallopian Tube Cancer Fallopian Tube Diseases Fallopian Tube Neoplasms Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Gastrointestinal Diseases Gastrointestinal Neoplasms Genital Diseases Genital Diseases, Female Genital Diseases, Male Genital Neoplasms, Female Genital Neoplasms, Male Gonadal Disorders Head and Neck Neoplasms Hematologic Diseases Hemic and Lymphatic Diseases Immune System Diseases Immunoproliferative Disorders Intestinal Diseases Intestinal Neoplasms Kidney Diseases Kidney Neoplasms Laryngeal Diseases Laryngeal Neoplasms Leukemia Liver Diseases Liver Neoplasms Lung Cancer Lung Diseases Lung Neoplasms Lymphatic Diseases Lymphoma Lymphoproliferative Disorders Male Urogenital Diseases Musculoskeletal Diseases Neoplasms Neoplasms by Histologic Type Neoplasms by Site Nervous System Diseases Nervous System Neoplasms Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Ovarian Cancer Ovarian Diseases Ovarian Neoplasms Pancreatic Cancer Pancreatic Diseases Pancreatic Neoplasms Peritoneal Cancer Prostate Cancer Prostatic Diseases Prostatic Neoplasms Rectal Diseases Rectal Neoplasms Respiratory Tract Diseases Respiratory Tract Neoplasms Skin Diseases Skin Neoplasms Skin and Connective Tissue Diseases Spinal Cord Cancer Stomach Diseases Stomach Neoplasms Thoracic Neoplasms Urinary Bladder Diseases Urinary Bladder Neoplasms Urogenital Diseases Urogenital Neoplasms Urologic Diseases Urologic Neoplasms Uterine Cervical Diseases Uterine Cervical Neoplasms Uterine Diseases Uterine Neoplasms Vulvar Diseases Vulvar Neoplasms

Sex eligibility

All sexes

Study type

Observational

Primary location

UT Southwestern, Dallas, Texas, United States

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About this study

The Study will collect combined clinical and molecular health information for cancer patients in the United States from multiple academic medical centers and community oncology practices. Participants who agree to join the Study will have their molecular profiling results, associated clinical health information, and longitudinal outcomes health information collected by the participating Institution for submission to Tempus. The specific goal of the Study is to create an outcomes-based dataset for future research to improve cancer treatment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Solid or hematologic malignancy.
  • Willing and able to provide informed consent where required.
  • Has received or will receive genomic profiling.

Exclusion criteria

  • Individuals without the capacity to consent.
  • Prisoners at the time of enrollment.

Treatment and study plan

observation

Other

No Intervention

Primary outcomes

  1. Create robust data set of health information

    Time frame: Up to 10 years

    To create a robust data set of health information about cancer patients who receive comprehensive genomic profiling in order to facilitate future novel precision medicine research

Secondary outcomes

  1. Document clinical events for patients who have had comprehensive genomic profiling

    Time frame: Up to 10 years

    To document specific clinical events in relation to diagnosis, treatment, and outcomes for patients who have had comprehensive genomic profiling

  2. Evaluate longitudinal paired tissue and cell free molecular testing

    Time frame: Up to 10 years

    To evaluate the feasibility of longitudinal paired tissue and cell free molecular testing of participants with specific types of cancer, mutations, or therapies

Other outcomes

  1. Support prospective and retrospective research studies

    Time frame: Up to 10 years

    To support prospective and retrospective research studies on participants with specific cancer types

  2. Describe real world treatment outcomes

    Time frame: Up to 10 years

    To describe real world treatment outcomes (such as real-world response, real world duration of response, real world progression free survival, real world time to next treatment, real world time to treatment discontinuation, and overall survival)

  3. Review medical information for standard of care decisions and health outcomes

    Time frame: Up to 10 years

    To review medical information for standard of care decisions in the future and general health outcomes

Sponsors and collaborators

Lead sponsor

Tempus AI

Industry

Registry information

Official study title

Tempus Priority Study: An Observational Study of Patients Who Have Received Comprehensive Genomic Profiling

Important dates

Study start
2020
Primary completion
2026
Study completion
2030
First posted
Jan 5, 2022
Registry last updated
May 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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