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NCT Number: NCT02012699

Integrated Cancer Repository for Cancer Research

The iCaRe2 is a multi-institutional resource created and maintained by the Fred & Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rural hospitals and cancer centers. The iCaRe2 advances comprehensive studies of risk factors of cancer development and progression and enables the design of novel strategies for prevention, screening, early detection and personalized treatment of cancer. Centers with expertise in cancer epidemiology, genetics, biology, early detection, and patient care can collaborate by using the iCaRe2 as a platform for cohort and population studies.

Recruiting

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Key information

Conditions

Pancreatic Cancer Abdominal Neoplasms Adenoma Adenomatous Polyposis Coli Adenomatous Polyps Adnexal Diseases Anal Cancer Anus Diseases Anus Neoplasms Bile Duct Cancer Bile Duct Diseases Bile Duct Neoplasms Biliary Tract Diseases Biliary Tract Neoplasms Bladder Cancer Blood Protein Disorders Breast Cancer Breast Diseases Breast Neoplasms Cardiovascular Diseases Central Nervous System Cancer Central Nervous System Neoplasms Central Nervous System Tumor Colon Cancer Colonic Diseases Colonic Neoplasms Colorectal Neoplasms Colorectal Neoplasms, Hereditary Nonpolyposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities DNA Repair-Deficiency Disorders Digestive System Diseases Digestive System Neoplasms Duodenal Cancer Duodenal Diseases Duodenal Neoplasms Endocrine Gland Neoplasms Endocrine System Diseases Endometrial Cancer Endometrial Neoplasms Esophageal Cancer Esophageal Diseases Esophageal Neoplasms Familial Adenomatous Polyposis Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Gallbladder Cancer Gallbladder Diseases Gallbladder Neoplasms Gastric Cancer Gastrointestinal Diseases Gastrointestinal Neoplasms Gastrointestinal Stromal Tumors Genetic Diseases, Inborn Genital Diseases Genital Diseases, Female Genital Diseases, Male Genital Neoplasms, Female Genital Neoplasms, Male Gonadal Disorders Head and Neck Neoplasms Healthy Control Hematologic Diseases Hemic and Lymphatic Diseases Hemorrhagic Disorders Hemostatic Disorders Hypopharyngeal Cancer Hypopharyngeal Neoplasms Immune System Diseases Immunoproliferative Disorders Intestinal Diseases Intestinal Neoplasms Intestinal Polyposis Kidney Cancer Kidney Diseases Kidney Neoplasms Laryngeal Cancer Laryngeal Diseases Laryngeal Neoplasms Leukemia Lip Cancer Lip Diseases Lip Neoplasms Liver Cancer Liver Diseases Liver Neoplasms Lung Cancer Lung Diseases Lung Neoplasms Lymphatic Diseases Lymphoproliferative Disorders Lynch Syndrome Male Urogenital Diseases Melanoma Mesothelioma Metabolic Diseases Mouth Diseases Mouth Neoplasms Multiple Myeloma Nasal Cavity Cancer Nasopharyngeal Cancer Nasopharyngeal Diseases Nasopharyngeal Neoplasms Neoplasm Metastasis Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Connective Tissue Neoplasms, Connective and Soft Tissue Neoplasms, Germ Cell and Embryonal Neoplasms, Glandular and Epithelial Neoplasms, Mesothelial Neoplasms, Nerve Tissue Neoplasms, Plasma Cell Neoplasms, Unknown Primary Neoplastic Processes Neoplastic Syndromes, Hereditary Nervous System Diseases Nervous System Neoplasms Neuroectodermal Tumors Neuroendocrine Tumors Nevi and Melanomas Nose Diseases Nose Neoplasms Nutritional and Metabolic Diseases Oral Cavity Cancer Oropharyngeal Cancer Oropharyngeal Neoplasms Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Ovarian Cancer Ovarian Diseases Ovarian Neoplasms Pancreatic Diseases Pancreatic Neoplasms Paranasal Sinus Cancer Paranasal Sinus Diseases Paranasal Sinus Neoplasms Paraproteinemias Pathologic Processes Pathological Conditions, Signs and Symptoms Penile Cancer Penile Diseases Penile Neoplasms Peritoneal Diseases Peritoneal Neoplasms Peritoneal Surface Malignancies Pharyngeal Diseases Pharyngeal Neoplasms Plasma Cell Dyscrasia Prostate Cancer Prostatic Diseases Prostatic Neoplasms Rectal Cancer Rectal Diseases Rectal Neoplasms Respiratory Tract Diseases Respiratory Tract Neoplasms Salivary Gland Cancer Salivary Gland Diseases Salivary Gland Neoplasms Sarcoma Skin Cancer Skin Diseases Skin Neoplasms Skin and Connective Tissue Diseases Small Intestine Cancer Stomach Diseases Stomach Neoplasms Stomatognathic Diseases Testicular Cancer Testicular Diseases Testicular Neoplasms Thoracic Neoplasms Thymus Cancer Thymus Neoplasms Thyroid Cancer Thyroid Diseases Thyroid Neoplasms Thyroid Nodule Unknown Primary Tumor Ureter Cancer Ureteral Diseases Ureteral Neoplasms Urethral Cancer Urethral Diseases Urethral Neoplasms Urinary Bladder Diseases Urinary Bladder Neoplasms Urogenital Diseases Urogenital Neoplasms Urologic Diseases Urologic Neoplasms Uterine Diseases Uterine Neoplasms Vaginal Cancer Vaginal Diseases Vaginal Neoplasms Vascular Diseases

Age range

19 year–110 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Advent Health, Greenwood Village, Colorado, United States

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About this study

The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2.unmc.edu) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred & Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a multi-center, semantically interoperable and easily customizable cancer data resource, which is aimed at collecting, managing, mining and sharing the comprehensive, multi-dimensional cancer-related data on cancer patients and biospecimens (such as tumor specimens, germ line DNA, serum, urine, and plasma) collected from those individuals.

The iCaRe2 has been developed as an expansion of the biocomputing framework that initially included four multi-center collaborative registries: Pancreatic Cancer Collaborative Registry (PCCR), Breast Cancer Collaborative Registry (BCCR), Thyroid Cancer Collaborative Registry (TCCR), and Great Plains Health Informatics Database (GPHID; to enroll subjects with no history of cancer diagnosis at time of enrollment). The repository now includes: Thoracic Oncology Collaborative Registry (TOCR), GenitoUrinary Cancer Collaborative Registry (GUCARE), Head and Neck Cancer Collaborative Registry (HNCCR), Gastrointestinal & Abdominal Cavity Cancer Collaborative Registry (GACCaRe), Central Nervous System Tumor Collaborative Registry (CTCR), Leukemia and Myeloid Neoplasm Registry (LEMN) , Gynecological Cancer Collaborative Registry (GCCR), Sarcoma Collaborative Registry (SARCR), Melanoma Collaborative Registry (MELCR), Plasma Cell Dyscrasias Collaborative Registry (PDCR), Neuroendocrine Collaborative Registry (NETR), Non-Melanoma Skin Cancer Registry (NMSC) and Auxiliary Cancer Registry (ACR).

The iCaRe2 group elected to use a "confederation model", as opposed to a traditional registry or network model. The major advantages of a confederation model include the flexibility to use selected Centers for different research projects based on a Center's resources and expertise and the ability to have different strategies to address various research questions. A web-based registry iCaRe2 was developed and made available to any Center to participate in data collection and storage of cancer related data. The iCaRe2 provides a HIPAA compliant, secure, efficient and user-friendly mechanism for data and validation; utilization of standard vocabulary and data elements; and ad-hoc data reporting capabilities. The iCaRe2 serves as a collaboration platform for studies (including clinical trials) performed in centers with expertise in cancer biology, pathology, epidemiology, genetics, early detection, and patient care.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis/history of cancer
  • Risk for developing cancer or suspicious clinical findings
  • No history of cancer (normal control registry)
  • Able to provide informed consent
  • 19 years of age or older
  • English or Spanish speaking individuals

Exclusion criteria

  • Unable to provide informed consent because of cognitive impairment
  • Non-English or non-Spanish speaking individuals

Treatment and study plan

Primary outcomes

  1. Development and Implementation of a Web-based Cancer Collaborative Registry

    Time frame: 86 years

    This is a registry that will continue to accrue participants indefinitely.

Secondary outcomes

  1. Procurement and Banking of Excess Biological Material for Future Analysis

    Time frame: 86 years

    This is a registry that will continue to accrue participants indefinitely.

Other outcomes

  1. Collection and Banking of Blood, DNA, and Urine Samples for Future Studies

    Time frame: 86 years

    This is a registry that will continue to accrue participants indefinitely.

Study contacts

Contact information is provided by the study sponsor or research team.

Artem Pachikov

CONTACT

[email protected]

402-559-0568

Sponsors and collaborators

Lead sponsor

University of Nebraska

Other

Registry information

Acronym: iCaRe2

Important dates

Study start
2013
Primary completion
2099
Study completion
2099
First posted
Dec 16, 2013
Registry last updated
Jun 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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