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NCT Number: NCT02831335

Technical Development of Multi-Parametric Renocerebral MRI

The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a battery of cognitive tests.

Recruiting

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Key information

Conditions

Aging

Age range

21 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Center for Magnetic Resonance Research

Minneapolis, Minnesota, 55455, United States

Location status: Recruiting

Location contact

Xiufeng Li, PhD

CONTACT

[email protected]

612-625-8258

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • English-speaking as primary language
  • No hearing loss or uncorrected vision

Exclusion criteria

  • Lacking capacity to consent
  • Having known history of cardiovascular diseases (e.g., clinical stroke)
  • Having acute and chronic obstructive pulmonary disease
  • Having known history of renal diseases (e.g., acute kidney injury)
  • Having known history of cognitive disorder or psychiatric illness
  • Having known history of chemical dependence (e.g., alcohol and narcotics)
  • Being treated with stimulant medications, anticonvulsants, antihypertensives or ß-adrenergic blockers

Treatment and study plan

MRI

Other

Perform MRI studies

Group 4

Other

Perform MRI studies

Primary outcomes

  1. MRI measured perfusion for each group

    Time frame: Baseline

    MRI measurements will be summarized for each group by using mean and standard deviation or standard error.

  2. MRI measured vascular reactivity for each group

    Time frame: Baseline

    MRI measurements will be summarized for each group by using mean and standard deviation or standard error.

  3. Cognitive performance for each group

    Time frame: Baseline

    The total cognitive performance scores will be summarized for each group by using mean and standard deviation or standard error.

Study contacts

Contact information is provided by the study sponsor or research team.

Xiufeng Li, Ph.D.

CONTACT

[email protected]

6126258258

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Registry information

Important dates

Study start
2026
Primary completion
2030
Study completion
2032
First posted
Jul 13, 2016
Registry last updated
Oct 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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