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NCT Number: NCT06269939

Theory-Driven Manualized Approach to Improving New Learning and Memory in Healthy Aging and MCI

The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in an aging population.

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Key information

Conditions

Aging

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kessler Foundation

East Hanover, New Jersey, 07936, United States

Location status: Recruiting

Location contact

Nancy Moore

CONTACT

[email protected]

973-324-8450

About this study

Memory enhancing techniques have been incorporated into an 8-session treatment protocol, Strategy Based Training to Enhance Memory (STEM), designed to teach participants about each of the techniques, train them on how to apply the techniques in daily life and practice their application to daily life memory demanding situations. The protocol includes teaching participants over age 60 how to restructure a memory demanding situation in order to make optimal use of the techniques.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Inclusion Criteria:
  • read and speak English fluently

Exclusion criteria

  • prior stroke or neurological injury/disease (i.e. traumatic brain injury, Multiple Sclerosis, or Stroke).
  • history of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis).
  • significant alcohol or drug abuse history (inpatient treatment).
  • Benzodiazepines and steroid use
  • Diagnosis of dementia

Treatment and study plan

STEM

Behavioral

Memory technique training

Primary outcomes

  1. Verbal Leaning task

    Time frame: Three points in time: pre-treatment, immediately following treatment, and 6- months after treatment is completed]

    Change in total score from Open-Trial Selective Reminding Test (OT-SRT)

  2. Participation in Everyday life

    Time frame: Three points in time: pre-treatment, immediately following treatment, and 6- months after treatment is completed]

    Change in total score from Participation Assessment with Recombined Tools

Secondary outcomes

  1. Functional Neuroimaging

    Time frame: Two points in time: pre-treatment, immediately following treatment

    Change in total scores from memory task during fMRI scan

Study contacts

Contact information is provided by the study sponsor or research team.

Nancy Moore

CONTACT

[email protected]

19733248450

Sponsors and collaborators

Lead sponsor

Kessler Foundation

Other

Registry information

Official study title

Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in Healthy Aging and Mild Cognitive Impairment

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Feb 21, 2024
Registry last updated
Jul 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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