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Enrolling by Invitation

NCT Number: NCT07563387

taVNS for Speech and Language Recovery in Aphasia

The goal of this research study is to evaluate a novel approach to improving speech recovery in those with acquired apraxia of speech. We will enroll participants with apraxia of speech resulting from stroke or brain injury to complete several tasks and intervention. Testing will take place four times over the course of the study and intervention will take place 5 days a week for 16 weeks. Overall, you can expect to spend up to 17 weeks participating in this study.

Enrolling by Invitation

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Key information

Conditions

Aphasia Apraxia of Speech Apraxias Behavior Brain Diseases Brain Injuries Brain Injuries, Traumatic Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Communication Communication Disorders Craniocerebral Trauma Language Language Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Psychomotor Disorders Signs and Symptoms Speech Speech Disorders Stroke Trauma, Nervous System Vascular Diseases Verbal Behavior Wounds and Injuries

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Brooks Rehabilitation Clinical Research Center

Jacksonville, Florida, 32216, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults between 18-80
  • Native speakers of English or simultaneous bilinguals
  • At least 6 months post stroke or TBI
  • Diagnosed production type aphasia or apraxia of speech

Exclusion criteria

  • Additional cognitive or neurological impairments (Autism, schizophrenia, seizures, etc)
  • Language comprehension deficits
  • Medications that influence key neurotransmitters

Treatment and study plan

taVNS

Device

active vagus nerve stimulation

Sham taVNS

Device

sham vagus nerve stimulation

Primary outcomes

  1. Adverse events

    Time frame: 6 months

    Frequency and severity of adverse events will be monitored and evaluated for severity and impact on attrition.

  2. Compliance

    Time frame: 6 months

    Percentage of the population that remains engaged in the study and completes all stimulation sessions.

Secondary outcomes

  1. Change in speech production scores

    Time frame: 6 months

    Primary outcomes for this aim include the learning trajectory over 8 weeks of speech therapy as measured by weekly probes and the WAB when intervention is combined with taVNS versus control stimulation to determine the effect of taVNS on re-learning motor speech plans and the trajectory of motor speech recovery.

Sponsors and collaborators

Lead sponsor

University of Florida

Other

Collaborators

  • Eric Sorenson Motor Speech Program at Brooks Rehabilitation

Registry information

Official study title

Non-invasive Vagus Nerve Stimulation for Language Recovery in Aphasia

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
May 4, 2026
Registry last updated
May 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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