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NCT Number: NCT06700005

ReadMap: Reading in Stroke Alexia and Typical Aging

Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for pleasure, and reading signs in the community. Understanding the brain and cognitive basis of alexia could improve diagnosis and treatment of this important problem. In this study, the investigators will perform a large-scale behavioral and brain imaging study of stroke survivors and typical older adults to improve our understanding of the brain and cognitive basis of reading in both of these groups.

Participants will complete a battery of tests of reading, speech, language, and thinking abilities. In addition, some participants will complete an MRI. Sessions will be completed across approximately 2-6 weeks, but may be extended depending on participants' schedules and availability. Some participants will be invited to repeat these procedures once or twice in approximately 3-12 months to monitor for changes in reading abilities and MRI measurements over time.

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Key information

Conditions

Aphasia Alexia Apraxias Behavior Brain Diseases Brain Injuries Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Communication Communication Disorders Craniocerebral Trauma Dyslexia Language Language Disorders Learning Disabilities Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurodevelopmental Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Psychomotor Disorders Signs and Symptoms Specific Learning Disorder Speech Speech Disorders Stroke Trauma, Nervous System Vascular Diseases Verbal Behavior Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Georgetown University Medical Center

Washington D.C., District of Columbia, 20057, United States

Location status: Recruiting

Location contact

Alycia Laks, MS, CCC-SLP

CONTACT

[email protected]

202-687-5205

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Stroke Survivors:

  • Age >= 18
  • Learned English at 8 years or younger
  • Brain injury resulting from stroke

Controls:

  • Age >= 18
  • Learned English at 8 years or younger

Exclusion criteria

for all groups:

  • History of other brain disorder that could interfere with our ability to interpret results (e.g., Multiple sclerosis, dementia, head injury causing loss of consciousness)
  • Severe psychiatric condition that would interfere with participation in the study
  • History of diagnosed learning disorder
  • Hearing or vision loss that interferes with performance on behavioral tests even after correction with glasses/hearing aids.
  • Inability to follow study procedures despite maximal support

Additional exclusion criteria for MRIs:

  • Presence of metal in the body that is incompatible with MRI
  • Pregnancy
  • Claustrophobia

Treatment and study plan

Primary outcomes

  1. MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)

    Time frame: Collected within 1 month of behavioral testing

    Part of MRI sequence that measures deep grey matter structure.

  2. DTI (Diffusion Tensor Imaging)

    Time frame: Collected within 1 month of behavioral testing

    Part of MRI sequence that measures the rate of water diffusion between cells to understand and create a map of internal structures.

  3. Behavioral testing

    Time frame: Collected within 1 month of MRI

    Battery of standard clinical and in-house behavioral tests to measure speech, language, and cognition. Final score is derived from principle components analysis.

Study contacts

Contact information is provided by the study sponsor or research team.

Alycia Laks, MS, CCC-SLP

CONTACT

[email protected]

202-687-5205

Sponsors and collaborators

Lead sponsor

Georgetown University

Other

Collaborators

  • MedStar National Rehabilitation Network
  • National Institute on Deafness and Other Communication Disorders (NIDCD)

Registry information

Acronym: ReadMap

Important dates

Study start
2023
Primary completion
2028
Study completion
2028
First posted
Nov 21, 2024
Registry last updated
Nov 21, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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