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Completed

NCT Number: NCT01763697

Taste Acuity and Caloric Intake After Acute Morphine Administration

This study will investigate the effects of acute morphine administration on taste acuity and how much a person eats. It is hypothesized that there will be a dose dependent decrease in taste acuity and dose dependent increase in food intake associated with acute morphine administration. Knowledge from this study will impact the future of feeding behavior and obesity research in the general population. Results will also promote exploration of the long-term effect of opioid abuse on taste acuity and feeding behavior in substance abusing populations.

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Key information

Conditions

Taste Sweet Behavior Behavior, Animal Feeding Behavior Taste Salty

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Johns Hopkins Bayview Medical Center

Baltimore, Maryland, 21224, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adult male and female volunteers
  • Ages of 18 to 65

Exclusion criteria

  • History of drug dependence (including opioid use disorders)
  • History of taste dysfunction
  • Significant medical or Axis I psychiatric disorder
  • Any trauma or surgical procedures to the head or neck region
  • Medication or illicit drug more than 4 out of the last 30 days.
  • Pregnancy
  • Abnormal electrocardiogram findings
  • Negative rating of greater than 40% of the foods available for consumption

Treatment and study plan

taste acuity assessment

Behavioral

Quantitative measurement of for tasting detection and recognition thresholds, magnitude of perception and hedonic response.

Recorded meal

Behavioral

Primary outcomes

  1. Taste

    Time frame: 3 hours after dose administration

    The primary outcome variable will be the taste acuity profile, which includes the taste detection threshold, recognition threshold, magnitude estimation, and hedonic response.

Secondary outcomes

  1. Calories

    Time frame: 6 hours after dose administration

    The secondary outcome measure will be the amount of calories consumed over a 2 hours period following the drug administration.

Sponsors and collaborators

Lead sponsor

Johns Hopkins University

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Jan 9, 2013
Registry last updated
May 29, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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