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OpenTrials
Enrolling by Invitation

NCT Number: NCT07134621

Target Organ Damage in Patients With Repaired Coarctation of Aorta and Exercise Induced Hypertension

The goal of this observational study is to obtain data on the effect of exercise induced hypertension on target organs in adult patients with repaired coarctation of the aorta. The main questions it aims to answer are:

* patients with exercise induced hypertension have signs of hypertensive heart disease? * patients with exercise induced hypertension have increased arterial stiffness? * patients with exercise induced hypertension have signs of hypertensive renal damage? Participants will be invited for an outpatient appointment during which medical history and physical investigation will be performed. They will undergo cardiopulmonary exercise testing during which blood pressure will be measured regularly. Transthoracic echocardiography will also be performed as well as assessment of arterial stiffness by measuring pulse wave velocity. Renal function will be assessed by blood and urine analysis.

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Key information

Conditions

Coarctation of the Aorta Aortic Coarctation Cardiovascular Abnormalities Cardiovascular Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Heart Defects, Congenital Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

UMC Ljubljana

Ljubljana, 1000, Slovenia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult patients aged 18 years and older
  • history of coarctation of aorta repair

Exclusion criteria

  • haemodynamically significant recoarctation
  • arterial hypertension at rest
  • antihypertensive therapy
  • associated haemodynamically significant valvular heart disease
  • associated complex congenital heart disease
  • advanced heart failure
  • symptomatic arrhythmias
  • cognitive or physical limitations to perform exercise stress testing

Treatment and study plan

Primary outcomes

  1. Number of patients with EIH who also have signs of hypertensive heart disease.

    Time frame: At enrolment.

  2. Number of patients with EIH and increased arterial stiffness.

    Time frame: At enrolment.

  3. Number of patients with EIH and signs of hypertensive renal damage.

    Time frame: At enrolment.

Sponsors and collaborators

Lead sponsor

University Medical Centre Ljubljana

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 21, 2025
Registry last updated
Apr 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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