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NCT Number: NCT05248763

Taiwan Cancer Moonshot Project

The aim of this study is to establish multiomic big data under strictly collected clinical samples from tumors, adjacent normal tissue, blood, and clinical data then analyze by using integrated proteomics and genetics platform.

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Key information

Conditions

Malignant Neoplasm of Body of Stomach in Situ Adnexal Diseases Breast Diseases Breast Neoplasms Digestive System Diseases Digestive System Neoplasms Endocrine Gland Neoplasms Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Gastrointestinal Diseases Gastrointestinal Neoplasms Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Gonadal Disorders Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Ovarian Diseases Ovarian Neoplasms Pancreatic Diseases Pancreatic Neoplasms Respiratory Tract Diseases Respiratory Tract Neoplasms Skin Diseases Skin and Connective Tissue Diseases Stomach Diseases Stomach Neoplasms Thoracic Neoplasms Urogenital Diseases Urogenital Neoplasms

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

National Taiwan University Hospital

Taipei, 100225, Taiwan

Location status: Recruiting

Location contact

Ming-Shiang Wu, M.D., PhD

CONTACT

About this study

Multiomic integrative analysis is an effective strategy to facilitate the investigation of molecular mechanism, cause, and early intervention of specific diseases. Gastric cancer is specifically chosen for our research target to decrease its incidence and improve survival. To increase precision diagnosis, prognosis and precision therapy, patients from Taiwan are selected as cohort subjects. The aim of this study is to establish multiomic big data under strictly collected clinical samples from tumors, adjacent normal tissue, blood, and clinical data then analyze by using integrated proteomics and genetics platform. Genome, transcriptome, genomic methylation, proteomics, and post-translational modification will be used to construct a map for determine the in-depth carcinogenesis of gastric cancer and strategies for cancer early diagnosis, prevention, and targeted treatments.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • lung cancer, breast cancer, gastric cancer, pancreatic cancer, ovarian cancer

Exclusion criteria

  • other cancer types

Treatment and study plan

Primary outcomes

  1. Collected clinical samples from tumors, adjacent normal tissue, blood, and clinical data

    Time frame: Through study completion, an average of 2 to 3 year

    Analyze collected clinical samples by using integrated proteomics and genetics platform (genome, transcriptome, genomic methylation, proteomics, and post-translational modification)

Secondary outcomes

  1. Differential expressed genes and proteins in tumor

    Time frame: Through study completion, an average of 4 year

    The relative difference, or fold change of expressed genes and proteins (tumors vs adjacent normal tissue)

Study contacts

Contact information is provided by the study sponsor or research team.

Yu-Ju Chen, PhD

CONTACT

[email protected]

886-2-55728660

Sponsors and collaborators

Lead sponsor

Academia Sinica, Taiwan

Other

Collaborators

  • National Taiwan University Hospital

Registry information

Official study title

Taiwan Cancer Moonshot Project: 1. Next-generation Pathway of Taiwan Cancer Precision Medicine (Subjective Aim 1- Taiwan Cancer Moonshot Project); 2. Development of Novel Treatments for Major Diseases (Subproject 5 - Multiomic Big Data-based Intelligent Navigation System for Precision Oncology)

Important dates

Study start
2022
Primary completion
2026
Study completion
2035
First posted
Feb 21, 2022
Registry last updated
Jul 20, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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