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OpenTrials
Completed

NCT Number: NCT03658343

T2* MRI Analysis for Sarcoma

T2* imaging is a method to identify labile iron pools in tumor cells. These iron pools may be linked to better treatment outcomes for specific types of therapy. This is a small pilot study to see if radiation therapy changes the amount of iron in a sarcoma tumor.

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Key information

Conditions

Radiotherapy Magnetic Resonance Imaging Neoplasms Neoplasms by Histologic Type Neoplasms, Connective and Soft Tissue Sarcoma

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • pathologically confirmed Sarcoma, by biopsy or excision
  • prescribed radiation therapy as per standard of care
  • treatment to begin within 5 weeks after surgery or biopsy
  • ECOG 0, 1, or 2
  • ability and willingness to provide informed consent

Exclusion criteria

  • < 18 years of age

Treatment and study plan

T2* Imaging

Diagnostic Test

T2* imaging sequences for MRI

Other names: magnetic resonance imaging, T2-star, T2* MRI

Primary outcomes

  1. Change in ferric iron levels detected by T2* MRI

    Time frame: baseline and 8 weeks

    Change from baseline in Fe3+ iron levels

Secondary outcomes

  1. Change in ferrous iron levels detected by T2* MRI

    Time frame: Baseline and 8 weeks

    Change from baseline in Fe2+ iron levels

Sponsors and collaborators

Lead sponsor

Bryan Allen

Other

Collaborators

  • Holden Comprehensive Cancer Center
  • National Cancer Institute (NCI)

Registry information

Official study title

An Exploratory, Pilot Study Evaluating T2* Imaging for Adult Sarcoma

Important dates

Study start
2018
Primary completion
2022
Study completion
2022
First posted
Sep 5, 2018
Registry last updated
Feb 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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