Skip to main content
OpenTrials
Completed

NCT Number: NCT07403175

Synergistic Impact of Postural Correction Interventions and Sustained Natural Apophyseal Glides in Migraine

This study was conducted to evaluate the synergistic impact of postural correction interventions and sustained natural apophyseal glides on severity, quality of life and disability in patients with migraine.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Migraine Brain Diseases Central Nervous System Diseases Headache Headache Disorders Headache Disorders, Primary Migraine Disorders Nervous System Diseases Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

22 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Abdul Ahaad Hospital, Sialkot

Sialkot, Punjab Province, 51413, Pakistan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • A diagnosis of episodic migraine made by the primary investigator according to ICHD-2.
  • Symptoms must include at least two of the following: Unilateral pain, Pulsating/throbbing pain, Nausea, Vomiting, Photophobia/phonophobia.
  • Participants should be full time employees or Desktop users.
  • Participants have a history of at least migraine >4 days per month.
  • Participants having history of migraine lasting from 4-72 hours
  • Age group between 22 and 45 years.
  • Both gender male and female.
  • Participants who agree to cut-off any pharmacological treatment during study.
  • Participants should have an average score between 3-6 on pain intensity scale.

Exclusion criteria

  • Participants having active migraine and other headache types e.g. Cluster headache.
  • Previous neck/head trauma from >2 years.
  • Any neck/head surgery >2 years
  • Spinal infections/diseases e.g. Tumor, TB spine
  • Any history of neurological disorders e.g. stroke, abcess, haemorrhage, haematoma
  • Severe Osteoporosis
  • Pregnancy
  • Upper motor neuron disease, cervical stenosis, and metabolic diseases in bone and joint.
  • Ongoing radiotherapy, chemotherapy, steroid therapy, or anticoagulants.
  • Psychiatric diseases such as phobia/obsession and depression.

Treatment and study plan

sustained natural apophyseal glides

Other

Headache SNAG: A posteroanterior mobilization of the second cervical vertebrae is maintained for 10-30 seconds having the patient comfortably seated on a chair or couch. A maximum of six repetitions were administered. The patient is administered SNAG mobilization by placing the medial border of the thumb's distal phalanx on the spine of one vertebra above while standing behind the patient. The thumb tips were positioned at a 45° angle, and another thumb is used to provide the glides. Glides are performed in 3 sets and 6 times during the session.

Reverse Headache SNAG: Anterio-posterior mobilization of the second cervical vertebrae is maintained for 10-30 seconds having the patient comfortably seated on a chair or couch. A maximum of 6 repetitions were administered.

Other names: SNAGs

postural correction exercises

Other

The main exercises used in this group are stretching, strengthening, and endurance exercise to maintain a healthy posture and correct the faulty posture due to weakened and tightened muscles Each subject will receive 6 treatment sessions spread over 4 consecutive weeks and each treatment session will not extend beyond 30 min.

  • Stretching exercises
  • Levator scapulae stretching
  • Upper trapezius stretching
  • Scalenes muscle stretching
  • Pectoralis major stretch
  • Pectoralis minor stretch
  • Sternocleidomastoid stretch
  • Strengthening Exercises
  • Lower trapezius strengthening
  • Rhomboids strengthening
  • Deep cervical flexors strengthening
  • Endurance Training

Conventional physical therapy

Other
  • Hot pack for 20 minutes on the neck region (upper trapezius) in sitting position.
  • Soft tissue mobilization includes deep tissue massage locally to the cervical region by applying pressure with fingers and palms.
  • Isometrics of neck in which the patient is seated on a chair or standing, or in a comfortable position having spine in a neutral position. Placing hands on patient's forehead by asking the patient to gently push head forward while simultaneously resisting the movement therapist's hands. Hold the contraction for 5-10 seconds, then relax. this movement was repeated in all directions.

Primary outcomes

  1. Numeric Pain Rating Scale (NPRS)

    Time frame: From enrollment to the end of treatment at 4 weeks.

    The NRS is used to gauge the patient's degree of pain. On a 0-10 scale, where 0 represents no pain, 1-3 represents mild pain, 4-6 represents moderate pain, and 7-10 represents severe pain, this tool is frequently used to gauge the intensity of pain. Patients rate how much pain they are currently experiencing as well as how much pain they have experienced in the past 24 hours. The patient's level of pain might be represented by the average of three evaluations or by any single value

  2. Migraine Specific Quality of Life Questionnaire (MSQ Version 2.1)

    Time frame: From enrollment to the end of treatment at 4 weeks.

    This questionnaire is used to evaluate migraine patient's quality of life. The 14-item MSQ version 2.1 measures QOL impacts in three domains: Role function-restrictive (RFR), which measures the functional impact of migraine through limitations on daily social and work activities; Role function-preventive (RFP), which measures the impact of migraine through prevention of daily work and social activities; and Emotional function (EF), which measures the emotional impact of migraine through three items. The raw total score was the sum of all item scores, which were rescaled from 0 to 100, with a higher score denoting better quality of life. Raw scores in each domain were calculated as the sum of all item scores.

  3. Migraine Disability Assessment Scale (MDA)

    Time frame: From enrollment to the end of treatment at 4 weeks.

    The Migraine Disability Assessment Scale (MIDAS) is intended to assist individuals and medical professionals in comprehending how migraines affect day-to-day living. MIDAS gives a more accurate view of the overall impact of migraines by evaluating how frequently they occur and how they interfere with social activities, employment, and domestic duties. It is simpler to customize therapy to meet each patient's needs when the information is used to determine treatment choices and monitor progress overtime. In the end, it's a tool that facilitates improved communication and assistance in migraine management by allowing patients to share their experiences and difficulties.

Secondary outcomes

  1. ROM Cervical Spine (Flexion)

    Time frame: From enrollment to the end of treatment at 4 weeks.

    Changes in cervical spine flexion ROM at baseline and 4th week of intervention was measured using goniometer.

  2. ROM Cervical Spine (Extension)

    Time frame: From enrollment to the end of treatment at 4 weeks.

    Changes in cervical spine extension ROM at baseline and 4th week of intervention was measured using goniometer.

  3. ROM Cervical Spine (Lateral Flexion) Left Side

    Time frame: From enrollment to the end of treatment at 4 weeks.

    Changes in cervical spine lateral flexion on left side ROM at baseline and 4th week of intervention was measured using goniometer.

  4. ROM Cervical Spine (Lateral Flexion) Right Side

    Time frame: From enrollment to the end of treatment at 4 weeks.

    Changes in cervical spine lateral flexion on right side ROM at baseline and 4th week of intervention was measured using goniometer.

  5. ROM Cervical Spine (Rotation) Left Side

    Time frame: From enrollment to the end of treatment at 4 weeks.

    Changes in cervical spine rotation on left side ROM at baseline and 4th week of intervention was measured using goniometer.

  6. ROM Cervical Spine (Rotation) Right Side

    Time frame: From enrollment to the end of treatment at 4 weeks.

    Changes in cervical spine rotation on right side ROM at baseline and 4th week of intervention was measured using goniometer.

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Synergistic Impact of Postural Correction Interventions and Sustained Natural Apophyseal Glides on Severity, Disability and Quality of Life in Patients With Migraine

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Feb 11, 2026
Registry last updated
Feb 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.