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OpenTrials
Completed

NCT Number: NCT00445276

Symptomatic Efficacy of Diacerein in Knee Osteoarthritis

Pain is the main symptom of osteoarthritis that motivates medical visits. Diacerhein has already demonstrated its efficacy in knee and/or hip osteoarthritis. This study aims at confirming the efficacy of diacerhein in symptomatic knee osteoarthritis using known and validated criteria and according to the recommendations and guidelines for this kind of study.

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Key information

Conditions

Knee Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Chu Trousseau

Tours, 37044, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Painful primary osteoarthritis (VAS ≥ 40 mm)
  • Radiologically proven (Kellgren & Lawrence grade I to III)
  • Requiring the prescription of a symptomatic treatment of pain

Exclusion criteria

  • Severe associated diseases
  • Wash-out: AINS, Coxibs, Paracetamol, anti-osteoarthritic treatments, hyaluronic acid, knee tidal lavage
  • Other osteoarticular disease

Treatment and study plan

Diacerein

Drug

Primary outcomes

  1. VAS on pain movement, WOMAC A 1.1 section

Secondary outcomes

  1. WOMAC : total, pain, physical function

  2. Paracetamol consumption

  3. Global assessment of the patient

  4. Responder patients with OMERACT-OARSI criteria

  5. Tolerance

Sponsors and collaborators

Lead sponsor

Laboratoires NEGMA

Industry

Registry information

Official study title

Efficacy Study of Diacerein in the Symptomatic Treatment of Knee Osteoarthritis

Important dates

Study start
2005
Primary completion
2006
Study completion
2006
First posted
Mar 8, 2007
Registry last updated
Mar 4, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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