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Completed

NCT Number: NCT01127698

Swedish Mammography Cohort

The Swedish Mammography Cohort began in 1987-1990, when 66,651 women living in two counties in central Sweden completed a mailed questionnaire that included items about their diet, parity, age at first child's birth, history of breast cancer in family, weight, height, and education. Follow-up questionnaires have been sent out in 1997 and in 2008-09.

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Key information

Conditions

Cancers Bone Diseases Bone Diseases, Metabolic Cardiovascular Diseases Cataract Digestive System Diseases Eye Diseases Fractures Fractures, Bone Gastrointestinal Diseases Lens Diseases Metabolic Diseases Musculoskeletal Diseases Neoplasms Nutritional and Metabolic Diseases Osteoporosis Wounds and Injuries

Age range

40 year–74 year

Sex eligibility

Female

Study type

Observational

About this study

From 1987 to 1990 a population-based mammography screening program was introduced in two counties in central Sweden. In Västmanland County all women born between 1917 and 1948 received a mailed invitation to be screened by mammography between March 1987 and March 1989 (n=41,786) together with a 6-page questionnaire; 31,735 women (76%) returned the completed questionnaires. In Uppsala County all women born between 1914 and 1948 were invited to the screening and received the same questionnaire between January 1988 and December 1990 (n=48517); 34916 women (72%) returned the completed questionnaires. Hence, questionnaires completed before undergoing mammography were obtained from 66,651 women (74%) in the source population. These questionnaires included items about diet, parity, age at first child's birth, history of breast cancer in family, weight, height, and education.

In 1997 a second questionnaire was sent to all cohort members who were still living in the study area. The questionnaire updated information about diet and was extended to include information on physical activity, medical history, age at menarche, history of oral contraceptive use, age at menopause, postmenopausal hormone use and lifestyle factors such as cigarette smoking history and use of dietary supplements. Majority of questions in the questionnaires have been validated.

During 2008-09, the exposure information was updated and extended by sending out two new questionnaires - one questionnaire on health including several signs of symptoms, sleeping, social relations etc (2008) and one on diet, dietary supplement use, and lifestyle factors (2009).

Incident cases of cancer are ascertained by record linkages of the study population with the National Swedish Cancer Register and the Regional Cancer Registers. Cardiovascular and other diseases as well as surgeries and causes of death are identified by linkage to the National Inpatient and other registries at the Swedish Board of Health and Welfare. Ascertainment of cancer cases and other diseases is almost 100% complete. Dates of deaths are ascertained through the Swedish Death Register (100% complete), and information on date of moving out of the study area is obtained by linkage with the Swedish Population Register.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All women born between 1914 and 1948, living in central Sweden

Exclusion criteria

  • None

Treatment and study plan

Primary outcomes

  1. Breast cancer

    Time frame: 1987-2010

  2. Colorectal cancer

    Time frame: 1987-2010

  3. Endometrial Cancer

    Time frame: 1987-2010

  4. Ovarian cancer

    Time frame: 1987-2010

  5. Pancreatic cancer

    Time frame: 1987-2010

  6. Stomach cancer

    Time frame: 1987-2010

  7. Kidney cancer

    Time frame: 1987-2010

  8. Bladder cancer

    Time frame: 1987-2010

  9. Cardiovascular diseases

    Time frame: 1987-2010

  10. Mortality

    Time frame: 1987-2010

  11. Cataract

    Time frame: 1987-2010

  12. Fractures, hip fractures

    Time frame: 1987-2014

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Collaborators

  • Harvard School of Public Health (HSPH)

Registry information

Acronym: SMC

Important dates

Study start
1987
Primary completion
1990
First posted
May 21, 2010
Registry last updated
Feb 28, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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