Surviving the Pediatric Intensive Care Unit (PICU)

The objectives of Helping to Optimize Patients' Experiences (HOPE) after Pediatric Critical Illness Cohort Study are:

• [Primary] To characterize physical and cognitive health outcomes of PICU survivors.
• [Primary] To investigate subgroups of critically ill children who have poor medium-term physical and cognitive health outcomes.
• [Primary] To elucidate risk factors for poor physical and cognitive health outcomes in PICU survivors.
• [Exploratory] To investigate the impact of physical and cognitive health of PICU survivors on overall family health.

The objectives of Singapore Health outcomes After Critical illness in Kids - Siblings (SHACK-S): Health Outcomes and Experiences of Healthy Siblings in the first 6 months after PICU discharge are:

• [Primary] To describe and compare quality-of-life in healthy siblings at 1, 3 and 6 months after PICU discharge.
• [Primary] To explore the experiences and support needs of healthy siblings 6 months after PICU discharge of a critically ill child.
• [Secondary] To examine the experiences of recovery trajectory of healthy siblings.

Thus, HOPE cohort will provide information and insight regarding which groups of PICU patients and associated PICU therapies are associated with the highest risk for poor survivorship. The conduct of this study will also allow us to identify the challenges and find appropriate solutions in performing a cohort study with an emphasis on patient-reported outcomes (e.g., functional status, cognition and quality of life). Concurrently, the SHACK-S cohort will provide insights to understand the impacts of PICU admission on siblings and their recovery.

Inclusion criteria

[HOPE Cohort]

• Between 28 days - 16 years of age at PICU admission
• Have an expected PICU stay > 48 hours*

[SHACK-S Cohort]

• Healthy children (aged 4 -16 years old) with critically ill sibling between 28 days - 16 years of age at PICU admission
• Has a critically ill sibling who has an expected PICU stay > 48 hours
• Lives in the same household as the critically ill sibling and parents prior to admission

Exclusion criteria

[HOPE Cohort]

• Do-Not-Resuscitate status
• Lack of informed consent
• Prior enrolment in this study

[SHACK-S Cohort]

• Children of critically ill sibling with Do-Not-Resuscitate status
• Children with condition listed on paediatric Complex Chronic Conditions (CCC) system Version 3.0 or with neurocognitive/neurodevelopmental delays or disorders
• Previous admission to PICU
• Lack of informed consent
• Prior enrolment in this study

• Note: For participating study sites without a dedicated PICU (e.g., sites where patients are managed in a combined ward under High Dependency (HD) or ICU status), PICU stay will be defined as the duration during which the patient is assigned an ICU status. The determination of ICU status will be made at the discretion of the respective site's study team and Site-PI.