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Completed

NCT Number: NCT06102668

Survival and PN Dependence in SBS Patients

Short bowel syndrome (SBS) is a rare condition resulting from the loss of portions of the small intestine, and can cause a spectrum of metabolic and physiologic disturbances.The objective of this study was to determine the longterm survival and parenteral nutrition dependence of adult patients with SBS.

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Key information

Conditions

Short Bowel Syndrome Digestive System Diseases Gastrointestinal Diseases Intestinal Diseases Malabsorption Syndromes Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

About this study

Short bowel syndrome (SBS), the most common form of intestinal failure, is a rare condition resulting from the loss of portions of the intestine, typically because of extensive surgical resection or loss of intestinal function. Patients with SBS often stuffer from intestinal insufficiency or intestinal failure because they are unable to maintain fluid and nutrient balances on a normal diet. SBS can cause various metabolic and physiologic disturbances. Although parenteral nutrition is a life-saving measure for many patients with SBS, patients with SBS is associated with decreased survival and parenteral nutrition (PN) dependence. Few studies have reported the survival and PN dependence in adult SBS patients in China.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients diagnosed with SBS.

Exclusion criteria

  • age <18 years; patients with active malignant tumors.

Treatment and study plan

Primary outcomes

  1. Survival

    Time frame: 2012/1/1-2019/1/1

    Survival rate in patients with SBS

  2. Parenteral nutrition dependence

    Time frame: 2012/1/1-2019/1/1

    Parenteral nutrition dependence in patients with SBS

Secondary outcomes

  1. Risk factors

    Time frame: 2012/1/1-2019/1/1

    Risk factors of mortality and parenteral dependence in patients with SBS

  2. Cause of death

    Time frame: 2012/1/1-2019/1/1

    Cause of death in patients with SBS at the end of follow-up

Sponsors and collaborators

Lead sponsor

The First Affiliated Hospital of University of Science and Technology of China

Other

Collaborators

  • Jinling Hospital, China

Registry information

Official study title

Long-term Survival and Parenteral Nutrition Dependence in Adult Patients With Non-malignant Short Bowel Syndrome

Important dates

Study start
2012
Primary completion
2019
Study completion
2019
First posted
Oct 26, 2023
Registry last updated
Oct 26, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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