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Completed

NCT Number: NCT06046898

Surface Mechanomyography Using a Parasternal Patch to Measure and Detect Respiratory Drive and Effort

Surface mechanomyography (sMMG) has been proposed as a tool to study muscle mechanical activity. sMMG is a noninvasive technique using specific transducers to record muscle surface oscillations due to mechanical activity of the motor units . It could be of major interest for the detection of respiratory efforts in patients with respiratory failure. This study aims at assessing the performances of sMMG to measure and detect respiratory drive and effort in healthy volunteers.

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Key information

Conditions

Acute Respiratory Failure

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Angers University Hospital

Angers, 49000, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy volunteer
  • Age > 18 and < 60
  • Informed consent
  • Fasting
  • Subjects covered by or having the rights to medical care assurance

Exclusion criteria

  • Obesity (BMI > 30 kg.m-2)
  • Respiratory disease
  • Cardiovascular disease
  • Contraindication to the insertion of a nasogastric tube
  • Incapacity to consent
  • Pregnancy, breastfeeding
  • Bad understanding of the French language,
  • Other protected person according to articles L1121.7 and L1121.8 of the French Public Health Act.

Treatment and study plan

non-invasive ventilation with or without resistance

Device

non-invasive ventilation with or without resistance.

Primary outcomes

  1. Accuracy of sMMG to detect respiratory effort

    Time frame: 5 minutes after the beginning of recording

    Delays between the beginning of the respiratory effort detected by sMMG and Eadi and the end of the respiratory effort detected by sMMG and Eadi (msec)

Secondary outcomes

  1. Comparison between sMMG-time (MMG-TP) and PTPes-Pes Peak

    Time frame: 5 minutes after the beginning of recording

    Accuracy of sMMG to assess the intensity of respiratory effort (in comparison with pressure-time product in cm H2O.s.min-1)

  2. Comparison between sMMG slope & Eadi parameters

    Time frame: 5 minutes after the beginning of recording

    Accuracy of sMMG to assess the intensity of respiratory drive (in comparison with Eadi in microvolt)

  3. Comparison between sMMG slope & slope Peso

    Time frame: 5 minutes after the beginning of recording

    Accuracy of sMMG to assess the intensity of respiratory drive (in comparison Peso in cm H20)

  4. Delay between neural time measured by sMMG and neural time measured by Eadi

    Time frame: 5 minutes after the beginning of recording

    Accuracy of sMMG to assess the duration of inspiratory neural time (in comparison with Eadi in msec)

Sponsors and collaborators

Lead sponsor

University Hospital, Angers

Other Gov

Registry information

Official study title

Performance of Surface Mechanomyography Using a Parasternal Patch to Measure and Detect Respiratory Drive and Effort in Healthy Volunteers - PATCH-MMG

Acronym: PATCH-MMG

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Sep 21, 2023
Registry last updated
Mar 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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