NCT Number: NCT07245979
The goal of this clinical trial is to learn if the six-month supplementation with sirtuin activators can affect metabolism in 40-to-65-year old women with increased body weight. The main questions it aims to answer are:
Does sirtuin activators affect lipid and carbohydrate metabolism? Does sirtuin activators affect oxydative stress, immune functions and cell ageing?
Researchers will compare sirtuin activators to a placebo (a look-alike substance that contains no drug) to see if drug sirtuin activators works to improve metabolic status.
Participants will:
Take sirtuin activators or a placebo every day for 6 months. Visit the university once every 3 months for checkups and tests.
Interested in participating?
Request Info40 year–65 year
Female
Interventional
Not applicable
Poznan, Poland
Location status: Recruiting
Agata Chmurzynska, Professor
CONTACT
Agata Jankowska
SUB_INVESTIGATOR
Agata Muzsik-Kazimierska
SUB_INVESTIGATOR
Agnieszka Seremak-Mrozikiewicz
SUB_INVESTIGATOR
Emilia Zawieja
SUB_INVESTIGATOR
Grażyna Kurzawińska
SUB_INVESTIGATOR
Marcin Sadowski
SUB_INVESTIGATOR
Monika Mlodzik-Czyzewska
SUB_INVESTIGATOR
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Sirtuin acitivators supplementation for 6 months
Placebo supplementation for 6 months
Time frame: 6 months, two measurements: at month 0 and 6
Total cholesterol, Triacyglycerols, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesteroll
Time frame: 6 months, two measurements: at month 0 and 6
Blood glucose concentration
Time frame: 6 months, two measurements: at month 0 and 6
transcription level of the p16INK4a gene in peripheral blood mononuclear cells
Time frame: 6 months, two measurements: at month 0 and 6
telomere lenght measured in DNA isolated from whole blood
Time frame: 6 months, two measurements: at month 0 and 6
SA beta galactosidase activity
Time frame: 6 months, two measurements: at month 0 and 6
activities of oxidative stress enzymes in blood
Time frame: 6 months, two measurements: at month 0, 3 and 6
Measured in kg
Time frame: 6 months, two measurements: at month 0, 3 and 6
Body composition will include percent body fat and lean body mass measured with air displacement plethysmography
Time frame: 6 months, two measurements: at month 0, 3 and 6
Measured in cm
Time frame: baseline
Nucleotite variants at certain genomic position will be analysed
Contact information is provided by the study sponsor or research team.
Poznan University of Life Sciences
Other
Assessment of the Effect of Sirtuin Activator Supplementation on Cellular, Metabolic and Anthropometric Parameters in Women
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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