Skip to main content
OpenTrials
Completed

NCT Number: NCT05216991

Sugammadex and Quantitative Monitoring in "Fast-Track Anesthesia" During Liver Transplantation

The purpose of this research is to estimate the frequency of postoperative lasting muscle weakness in patients receiving Sugammadex after undergoing liver transplant surgery by using electromyographic device (EMG), such as TetraGraph.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Liver Transplant Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic Florida

Jacksonville, Florida, 32224, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients willing to participate and provide an informed consent.
  • Patients undergoing primary liver transplantation.

Exclusion criteria

  • Patients with unilateral disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.
  • Patients with systemic neuromuscular diseases such as myasthenia gravis.
  • Patients with a known history of cerebrovascular accident (CVA).
  • Patients undergoing repeat liver transplantation or concomitant pancreas/kidney transplantation at the time of liver transplantation.
  • Patients admitted to the intensive care unit prior to liver transplantation.

Treatment and study plan

TetraGraph on dominant hand

Other

Using standard of care TetraGraph device on dominant hand

TetraGraph on non-dominant hand

Other

Using standard of care TetraGraph device on non-dominant hand

Primary outcomes

  1. Incidence of Postoperative Residual Weakness in the Recovery Room

    Time frame: Approximately 10 minutes of surgery recovery period

    Number of patients to experience postoperative residual weakness after receiving Sugammadex as standard of care for liver transplant surgery. Postoperative residual weakness is defined as train-of-four ratio (TOF) <0.9. Train-of-four is a test used to measure the level of neuromuscular blockage through delivery of four consecutive stimuli to a nerve. Measurement of the muscle's response (number of twitches 1-4) to the stimuli indicates the degree of paralysis. This is measured by an EMG device placed on the thumb which is also part of standard of care for intraoperative assessment of muscle weakness. The ratio is calculated by comparing the amplitude of the fourth twitch to the first twitch. A TOF <0.9 indicates residual weakness, a TOF equal to or greater than 0.9 indicates no residual weakness.

Secondary outcomes

  1. ICU Admission

    Time frame: 30 days

    Number of patients to require ICU admission following liver transplantation

  2. Hospital Length of Stay

    Time frame: 30 days

    Average number of days patients are admitted to the hospital following liver transplantation

  3. Postoperative Pulmonary Complications

    Time frame: 30 days

    Number of participants who experienced postoperative pulmonary complications defined as pneumonia and respiratory failure

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

The Role of Sugammadex and Quantitative Monitoring in "Fast-Track Anesthesia" During Liver Transplantation

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Feb 1, 2022
Registry last updated
Oct 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.