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Completed

NCT Number: NCT07250919

Donor and Recipient Mismatch in Liver Transplantation

This observational study aims to investigate the impact of gender disparity between donors and recipients on long-term outcomes after liver transplantation (LT). The study aims to answer the following question:

Does gender mismatch lower the possibility of survival after liver transplantation? Participants demonstrate gender dicrepancies between donors and recipients as regular concept in LT. The retrospective cohort study investigates the impact over a long-term follow up of 10 years.

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Key information

Conditions

Patient Survival Digestive System Diseases Graft Survival Liver Disease (Alcoholic or Not) Liver Diseases Liver Transplant Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ajmera Transplant Centre, Toronto General Hospital, University Health Network, Toronto

Toronto, Ontario, Canada

About this study

The study involves patients who undergo liver transplantation at the Ajmera Transplant Centre Toronto from 2014 until 2022. The observation period ended at the first January 2025 to provide a minimal follow up of 24 months.

Liver transplant recipients with gender mismatch (A) will be compared with liver transplant recipients without gender mismatch (B).

Liver transplantation is the only curative treatment for people with end stage liver disease. Gender mismatch between donor and recipient, particularly, the combination of a female donor to male recipient has been controversial in the past. Identifying risk factors that could affect the survival of the graft and recipient is of the utmost importance.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients over the age of 18

Exclusion criteria

  • Cases of retransplantation
  • Combined organ transplantation
  • Cases with >30% of missing values

Treatment and study plan

Primary outcomes

  1. Patient survival

    Time frame: Liver transplantation between 01.01.2014 and 01.01.2022, Patient Survival: observatory period between 01.01.2014 and 01.01.2024

    Overall survival of patients who underwent liver transplantation at the Ajmera transplant centre toronto between 2014 and 2022

Sponsors and collaborators

Lead sponsor

University of Jena

Other

Collaborators

  • University Health Network, Toronto

Registry information

Official study title

Donor and Recipient Mismatch in Liver Transplantation - Time for Reconsideration?

Acronym: DR-MM in LT

Important dates

Study start
2014
Primary completion
2022
Study completion
2024
First posted
Nov 26, 2025
Registry last updated
Feb 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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