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Completed

NCT Number: NCT02800707

Sucralose, Stevia, Gut Microbiome and Glucose Metabolism

This study will determine the influence of two non-caloric sweeteners on glucose metabolism via the gut microbiome in adult men and women.

Completed

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Key information

Conditions

Impaired Glucose Tolerance Glucose Intolerance Glucose Metabolism Disorders Hyperglycemia Metabolic Diseases Nutritional and Metabolic Diseases

Age range

35 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

ECRC

Minneapolis, Minnesota, 55454, United States

About this study

This study will determine the influence of two non-caloric sweeteners on glucose metabolism via the gut microbiome in adult men and women aged 35-55 years.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Generally health adult men and women aged 35-55 years old -

Exclusion criteria

Adults will not be eligible who have chronic disease (cancer, CHD, diabetes, chronic kidney disease); pregnant or breast feeding; menopausal; has a history of bariatric surgery; taking prednisone/steroids, taking medication for PCOS, or take medications that influence blood glucose.

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Treatment and study plan

Sucralose

Other

Sweetner

Stevia

Other

Sweetner

Primary outcomes

  1. 2-hour glucose

    Time frame: 14 days

    An oral glucose tolerance test will be administered before and after consuming assigned sweetener to determine change in 2-hour glucose

Secondary outcomes

  1. Gut microbiome

    Time frame: 14 days

    Gut microbiota will be measured before and after consuming assigned sweetener to determine change in gut microbiota.

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Registry information

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Jun 15, 2016
Registry last updated
Mar 22, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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