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Completed

NCT Number: NCT04018105

Influence of Preprandial Metformin Administration on Carbohydrate Absorption

Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption.

It is usually recommended to take metformin during the meal to decrease gastrointestinal side effects. However, if metformin decreases carbohydrate absorption, this might not be the most efficient intake.

To study the influence of preprandial metformin administration on carbohydrate absorption, it will repeat 3 oral glucose tolerance test on obese dysglycemic patients, without metformin or with metformin administer 30 or 60 minutes before. We will also evaluate how it impacts gastrointestinal tolerance.

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Key information

Conditions

Impaired Glucose Tolerance Body Weight Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Intolerance Glucose Metabolism Disorders Hyperglycemia Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Type2 Diabetes

Age range

18 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Obesity (BMI ≥30 kg/m2)
  • Dysglycemia (HbA1c≥ 6,0 %)
  • No anti diabetic medication

Exclusion criteria

  • No obesity (BMI < 30 kg/m2)
  • No dysglycemia (HbA1c <6,0%)
  • Treatment that might interfere with carbohydrate absorption (anti diabetic medication, antibiotics, probiotics, steroids)
  • Anemia (Hb <12 g/dL)
  • Organ failure
  • Inflammatory Bowel Disease

Treatment and study plan

Oral glucose tolerance test (OGTT) with or without metformin

Other

Each participant will have 3 OGTT, one without metformin, one with metformin30 minutes before the test, one with metformin 60 minutes before the test. The order for each test will be randomized.

Primary outcomes

  1. Area under the curve of D-Xylose

    Time frame: During the 3 hours OGTT

Secondary outcomes

  1. Number of Participants with gastrointestinal side effects

    Time frame: During the 3 hours OGTT

  2. Area under the curve of blood glucose

    Time frame: During the 3 hours OGTT

  3. Area under the curve of insulin

    Time frame: During the 3 hours OGTT

  4. Area under the curve of GLP-1

    Time frame: During the 3 hours OGTT

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

Influence of Preprandial Metformin Administration on Carbohydrate Absorption: Pilot Randomized Controlled Study

Acronym: METTIME

Important dates

Study start
2021
Primary completion
2025
Study completion
2025
First posted
Jul 12, 2019
Registry last updated
Apr 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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