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Completed

NCT Number: NCT00647179

Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment

The purpose of this study is to investigate the effects of chronic elevated growth hormone on metabolism and insulin sensitivity by studying acromegalic patients before and after treatment.

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Key information

Conditions

Acromegaly Bone Diseases Bone Diseases, Endocrine Brain Diseases Central Nervous System Diseases Endocrine System Diseases Excessive Growth Hormone Secretion Glucose Metabolism Disorders Hyperinsulinism Hyperpituitarism Hypothalamic Diseases Insulin Resistance Metabolic Diseases Musculoskeletal Diseases Nervous System Diseases Nutritional and Metabolic Diseases Pituitary Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Endocrinology, Aarhus University Hospital

Aarhus C, Aarhus, DK-8000, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Written consent
  • Age between 18 and 70
  • Recently diagnosed with acromegaly

Exclusion criteria

  • NYHA 3
  • Uncontrolled hypertension
  • Known cerebrovascular disease
  • Proliferative retinopatia

Treatment and study plan

Transsphenoidal adenomectomy

Procedure

Surgery

Primary outcomes

  1. Insulin sensitivity

    Time frame: Before and after treatment

Secondary outcomes

  1. QoL, body composition, intrahepatic and intramyocellular fat, substrate metabolism, Glucose tolerance

    Time frame: Before and after treatment

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Collaborators

  • Aarhus University Hospital

Registry information

Important dates

Study start
2008
Primary completion
2016
Study completion
2016
First posted
Mar 31, 2008
Registry last updated
Dec 26, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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