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Completed

NCT Number: NCT01062529

Peripheral Metabolic Effects of Somatostatin

The aim of this study is to investigate peripheral effects of Somatostatin on glucose metabolism and growth hormone (GH) signalling in healthy men. Eight subjects will be enrolled. The hypothesis is that Somatostatin infusion reverses insulin resistance caused by GH.

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Key information

Conditions

Acromegaly Bone Diseases Bone Diseases, Developmental Bone Diseases, Endocrine Brain Diseases Central Nervous System Diseases Diabetes Diabetes Mellitus Dwarfism Dwarfism, Pituitary Endocrine System Diseases Glucose Metabolism Disorders Growth Hormone Deficiency Hyperinsulinism Hyperpituitarism Hypopituitarism Hypothalamic Diseases Insulin Resistance Metabolic Diseases Musculoskeletal Diseases Nervous System Diseases Nutritional and Metabolic Diseases Pituitary Diseases

Age range

18 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Medical department M

Aarhus, 8000, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI < 27 kg/m2
  • Written informed consent
  • Healthy

Exclusion criteria

  • Any disease
  • Any use of medications
  • Present or previous malignancy
  • Alcohol dependency
  • Allergy to trial medication

Treatment and study plan

Somatostatin

Drug

4 h of 150 microgram infusion

Primary outcomes

  1. Plasma levels of glucose

    Time frame: 3 months

Secondary outcomes

  1. GH signalling

    Time frame: one year

  2. Serum levels of free fatty acids (FFA)

    Time frame: one year

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Collaborators

  • The Ministry of Science, Technology and Innovation, Denmark

Registry information

Official study title

Peripheral Metabolic Effects of Intra Arterial Somatostatin Infusion in Healthy Controls

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Feb 4, 2010
Registry last updated
Jan 21, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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