Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

To describe the rates of microvascular complications (retinopathy, nephropathy, and peripheral neuropathy) and their relationships with HbA1c and diabetes duration in diverse cohort of adolescents and adults with CFRD for ≥5 years.

To describe macrovascular surrogates (resting blood pressure (BP), fasting lipids) and their relationship with HbA1c, diabetes duration and BMI in a diverse cohort with established CFRD.

This questionnaire will be used to describe the social determinants of health in the study population and their cross-sectional relationships with microvascular complications and macrovascular surrogates will largely be explored.

This questionnaire will be used to describe the social determinants of health in the study population and their cross-sectional relationships with microvascular complications and macrovascular surrogates will largely be explored.

This questionnaire ask questions regarding participants' physical activity, sleeping habits and substance use.

A self-evaluation questionnaire to assess child's pubertal development.

A questionnaire that asks the frequency and amount of beverage intake for the past month.

This is a questionnaire that asks participants regarding their CFRD care and the technology they use to help them manage diabetes.

This is a questionnaire that asks how participants manage their diabetes for the past 12 months.

Questionnaire that asks participants about possible diabetes-related issues they have experienced.

Questionnaire about what the parent or guardian of a participant may experience with their child's diabetes and rating how true it is for them over the past month.

A survey that consists of 25 questions and selecting from scale (0 = never to 4 = always) about how low blood sugar makes children feel and do.

Survey that consists of 25 questions about the frequency of things parents of children with diabetes sometimes do to keep from having low blood sugar.

A survey about various scenarios that may happen to the participant and rating how true it is for them over the past 6 months.

A 7 item scale that measures hypoglycemia awareness

A questionnaire that consists of 14 questions asking about the participant, their work and their home life.

This will be measured using a continuous glucose monitor that will be worn by the participant for 3 to 10 days.

This will be measured using the patient-related outcomes questionnaires.

Function will be assessed by collection of creatinine and Cystatin-C

This will be measured by liver enzymes and complete blood count (CBC); APRI and EMR data for liver imaging

This will measure diversity of individuals who were approached for study inclusion, who were recruited, who consented and who partially or fully completed study procedures as well as barriers and facilitators to recruitment.

A Sphygmocor XCEL device will be used to measure PWV/PWA (m/sec), pulse pressure amplification and augmentation index (Aix) and Aix adjusted to a HR of 75 (Aix-75).

The participant will complete 3-day recall of food intake using NIH's Automated Self-Administered 24-Hour (ASA24) Dietary Assessment Tool.

The participant will be required to wear an accelerometer device for 3 to 10 days to assess physical activity.

An oscillometric Spacelab monitors will be used to measure variables including SBP/DBP and BP load (%BP above 95th percentile for sex and height) for the 24-hour period and awake/sleep period. Sleep time will be determined from actigraphy and participant documentation.

Participant stool sample will be obtained for fecal elastase only for those for pancreatic sufficiency status is unclear.

Blood, urine and stool will be collected for biorepository.

The study will use the participants' addresses or part of their addresses (such as their zip codes) to allow researchers to look at how where they live might be related to their health through geocoding.