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Completed

NCT Number: NCT00514826

Study to Investigate Sleep Apnea Patients at Altitude

The purpose of the study is to investigate the effect of an altitude sojourn on patients with the obstructive sleep apnea syndrome

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Key information

Conditions

Obstructive Sleep Apnea Syndrome Apnea Dyssomnias Nervous System Diseases Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Pulmonary Division, University Hospital Zurich, Switzerland

Zurich, CH-8091, Switzerland

About this study

Previous observations do not allow to draw firm conclusions on the effect of altitude sojourn on sleep, breathing and daytime performance in patients with the obstructive sleep apnea syndrome. Furthermore, the susceptibility of sleep apnea patients to high altitude related illness is not known. Therefore, the purpose is to study untreated patients with obstructive sleep apnea syndrome living at low altitude during a sojourn of a few days at moderate altitude in order to evaluate the physiologic effects of hypobaric hypoxia in these patients. We hypothesize that: 1. Sleep and nocturnal breathing disturbances in untreated OSA patients are more pronounced at moderate altitude compared to low altitude. 2. The increase in sleep related breathing disturbances at moderate altitude is due to an increase in central apnea/hypopnea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Obstructive sleep apnea syndrome based on symptoms and a sleep study

Exclusion criteria

  • Sleep disorders other than obstructive sleep apnea syndrome
  • Other than mild, stable cardiovascular disease
  • Other than mild lung disease
  • Chronic rhinitis, previous uvulopalatopharyngoplasty
  • Treatment with drugs that affect respiratory center drive
  • Internal, neurologic or psychiatric disease that interferes with sleep quality
  • Previous intolerance to moderate or low altitude < 2600m

Treatment and study plan

Altitude exposure

Other

sojourn at moderate altitude (1860m and 2590m) during 2 days/nights each

Primary outcomes

  1. Prevalence and severity of sleep disordered breathing

    Time frame: during altitude sojourn

Secondary outcomes

  1. alterations in sleep structure and vigilance; high altitude related illness

    Time frame: during altitude sojourn

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Important dates

Study start
2007
Primary completion
2007
Study completion
2007
First posted
Aug 10, 2007
Registry last updated
May 26, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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