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Completed

NCT Number: NCT03358823

Study on the Brain Network of Angelman Syndrome

The aims of study on Angelman syndrome:

1. Establish the Angelman syndrome database 2. Explore the brain Network of Angelman Syndrome Based on Multi-modal Brain Image and Neural-EEG Data

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Key information

Conditions

Angelman Syndrome Abnormalities, Multiple Central Nervous System Diseases Chromosome Disorders Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Imprinting Disorders Movement Disorders Nervous System Diseases

Age range

Up to 18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Children's Hospital of Fudan University

Shanghai, Shanghai Municipality, 200232, China

About this study

  • The participants recruitment: from Chinese Angelman Syndrome Patients group (Angelhome : [email protected]) and Children's Hospital of Fudan University.
  • Fistly all participants had clinically and molecularly confirmed as Angelman syndrome . All participants should entry the online questionnaries and carified by telephone or on site . All the information will be recorded in the Angelman syndrome database. Investigators will analyze and summarize the relationship of phenotype and genotype(n=200).
  • Participants who assigned the informed consent and will undergo the brain MRI inspection and Neural-EEG recording in the Children's Hospital of Fudan University. The healthy age- and sex-matched control participants will enrolled in the same hospital. The Investigators will explore the brain morphology and electrophysiological alterations and for Angelman syndrome (AS) children among the different genotypes（n=200）.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical and molecular diagnosis of Angelman syndrome.
  • Agreed and completed the MRI scan and EEG-recording by using oral chloral hydrate.

Exclusion criteria

  • Reject MRI scan and EEG-recording by using oral chloral hydrate or unable to complete the scan.

Treatment and study plan

Primary outcomes

  1. Angelman syndrome databas; Brain Network of Angelman syndrome

    Time frame: 0-18 years old

    • Analysis of geneal situation of Chinese Angelman syndrome including phenotype ,genotype, brain image ,EEG data, living quality ,comorbidy evolulation(n=200)
    • Study on the Brain Network of Angelman Syndrome Based on Multi-modal Brain Image and Neural-EEG Data

Sponsors and collaborators

Lead sponsor

Fudan University

Other

Registry information

Official study title

Study on the Brain Network of Angelman Syndrome Based on Multi-modal Brain Image and Neural-EEG Data

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Dec 2, 2017
Registry last updated
Apr 26, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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