Study of the MyoScience Tissue Remodeling Device for Facial Rejuvenation

Inclusion criteria

• The subject must be a female 30 to 70 years of age.
• The subject must have a clinical examination prior to treatment including assessment of hyperdynamic line severity.
• The subject must have a wrinkle rating of at least "1" at rest in one or more of the following treatment areas (glabellar, lateral orbital, or frontalis).
• The subject must have signed an informed consent form.
• The subject should not have undergone any other facial cosmetic procedures at or above the level of the cheekbones within the past 6 months.
• The subject should not be participating in any other facial cosmetic research study.

Exclusion criteria

• The subject is on a regular regimen of prescribed or over-the-counter anticoagulants.
• The subject has an infection or skin problem at the injection site.
• The subject has a history of facial nerve palsy.
• The subject has marked facial asymmetry.
• The subject has ptosis.
• The subject has excessive dermatochalasis.
• The subject has deep dermal scarring.
• The subject has thick sebaceous skin.
• The investigator is unable to substantially lessen facial lines by physical separation.
• The subject has a history of neuromuscular disorder.
• The subject has undergone prior surgery that alters the subcutaneous anatomy of the areas being treated.
• Subjects with laxity of the canthal tendon and/or with lower lid retraction, and subjects who recruit their zygomaticus major muscle to animate their crow's feet.
• The subject has any physical or psychiatric condition that in the investigator's opinion would warrant exclusion from the study or prevent the subject from completing the study.