Study of the Molecular Genetics of Menstrual Migraine

Inclusion criteria

All cases and controls must:

• Be over 18 years
• Caucasian
• Provide written, informed consent
• Clearly understand and be able to comply with all the trial procedures, as required
• Not have taken part in trials of any investigational products within the previous 4 weeks

DNA Study:

• Cases must have at least a 12-month current or past history of menstrual migraine

RNA Study:

• Cases must have at least a 12-month current history of menstrual migraine
• Cases must have kept at least three months of headache diary data in advance of visit in order to confirm diagnosis
• Controls must still be having menstrual periods

Exclusion criteria

DNA Study:

• Cases and controls must not have smoked, chewed gum or consumed any food or drink in the 30 minutes prior to sample collection

RNA Study:

• Cases and controls will not be eligible for participation if they have:

• Polycystic ovarian syndrome;
• Taken any hormones or drugs in the previous three months that may affect normal hormone activity (e.g., hormonal contraceptives, hormone replacement therapy, dietary supplements such as isoflavones);
• Donated or lost a significant amount of blood (> 550 mL) within the previous 12 weeks
• Additionally, controls must not have a personal or family history in any first-degree relative of current or past migraine