Study of the Correlation Between Specific Genes and Cognitive Dysfunction After Surgery

The purpose of this study is to determine whether a certain clock-gene (HPER3) with the 5/5 genotype carries a higher risk of post-operative cognitive dysfunction.

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Key information

Conditions

Genotype Cognition Disorders Cognitive Dysfunction Cognitive Impairment Mental Disorders Neurocognitive Disorders

Age range

40 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Herlev Hospital - Gastro unit

Herlev, 2730, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients undergoing non-cardiac and non-neurological surgery in either regional or general anesthesia

Exclusion criteria

daily use of major tranquilizers or antipsychotic medication
known disease of the CNS
score less than 24/30 points in MMSE

Treatment and study plan

Genotyping

Genetic

Determination of 3 types of clock gene genotypes (HPER 4/4, 5/4, 5/5) on all blood samples

Primary outcomes

HPER3 genotype

Time frame: 3 months

Secondary outcomes

Post-operative morbidity

Time frame: ½ year

Sponsors and collaborators

Lead sponsor

Herlev Hospital

Other

Registry information

Official study title

The Correlation Between Certain Clock-gene Genotypes and POCD (Post-operative Cognitive Dysfunction)

Important dates

Study start: 2010
Primary completion: 2011
Study completion: 2011
First posted: Mar 17, 2010
Registry last updated: Jan 10, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed