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Completed

NCT Number: NCT05613517

Study of the Angle Lambda and Ocular Dominance

Anatomical ophthalmological connections and their dynamics are still debated in the scientific community. However, their considering is essential in many surgeries (strabismus, cataract, refractive...) or in clinical practice.

The correlation between these biometric values would make it possible to refine the knowledge related to these landmarks and thus offer better ophthalmological management by integrating these variables into the clinical examination.

The aim of the study is to analyze the correlation between the angle lambda and the ocular dominance depth in healthy individuals without ophthalmologic disorder.

Then, seconds goals were defined as the study of the relation between the value of the angle lambda and the fixation disparity quantified with the Rousseau test.

Relation between ocular dominance measured with the Guillon's test and the Hole-in-car test will also studied.

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Key information

Conditions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hôpital Necker-Enfants Malades

Paris, 75015, France

About this study

The angle lambda corresponds to the angle formed by the pupillary axis (line passing through the center of the pupil and perpendicular to the cornea) and the line of sight (broken line between the fixation point and the fovea and passing through the center of the pupil entrance). The angle kappa corresponds to the angle between the visual axis (line between the point of fixation and the fovea: area of the retina allowing precise vision) and the pupillary axis.

The angle lambda and the angle kappa are very close, which is why the lambda angle is often equated with the kappa angle, both in practice and in the literature.

The literature reports a non-null angle kappa ranged between 1.91° ± 0.14° and 5.73° ± 0.10° in the general population. Also, studies have reported a significantly greater angle on the left eye compared to the right eye. Moreover - because of the interpupillary difference - each eye perceives the same image from a different angle, resulting in a fixation disparity, defined as the angle of the residual deviation of the visual axes when the subject fixes and binocularly merges an image. In some cases, too high a value of the disparity can lead to a fixation disorder requiring orthoptic treatment.

Anatomical ophthalmological connections and their dynamics are still debated in the scientific community. However, their considering is essential in many surgeries (strabismus, cataract, refractive...) or in clinical practice.

The correlation between these biometric values would make it possible to refine the knowledge related to these landmarks and thus offer better ophthalmological management by integrating these variables into the clinical examination.

The aim of the study is to analyze the correlation between the angle lambda and the ocular dominance depth and the fixation disparity in a healthy population without ophthalmologic disorder.

Then, seconds goals were defined as the study of the relation between the value of the angle lambda and the fixation disparity quantified with the Rousseau test.

Relation between ocular dominance measured with the Guillon's test and the Hole-in-car test will also studied.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Informed major subject not opposing to their participation in the study

Exclusion criteria

  • Subject with strabismus or organic ophthalmologic pathology
  • Or presenting a visual acuity lower than 10/10th
  • Or with a history of eye surgery

Treatment and study plan

Eye examination

Other
  • orthoptic assessment (visual acuity, refraction, stereopsis test, Cover-test, evaluation of the disparity of fixation and ocular dominance, measurement of the inter-pupillary distance
  • ocular biometry
  • corneal topography
  • monocular photographs in photopic condition

Primary outcomes

  1. Value of the angle lambda

    Time frame: Day 0

    Semi-automatic digital method of measurement by eye photograph.

  2. Ocular dominance depth

    Time frame: Day 0

    Guillon's and Hole-In-Card tests.

Secondary outcomes

  1. Fixation disparity

    Time frame: Day 0

    Rousseau test.

  2. Ocular dominance measurements quantified by the Hole-in-the-card method

    Time frame: Day 0

    Ocular dominance.

  3. Guillon test

    Time frame: Day 0

    Ocular dominance.

  4. Semi-automatic method of measurement by ocular photography

    Time frame: Day 0

    Compare the values of the lambda angle obtained using the semi-automatic method of measurement by ocular photography and the method using corneal topography.

  5. Method using corneal topography

    Time frame: Day 0

    Compare the values of the lambda angle obtained using the semi-automatic method of measurement by ocular photography and the method using corneal topography.

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Collaborators

  • URC-CIC Paris Descartes Necker Cochin

Registry information

Official study title

Study of the Correlations Between the Ocular Dominance Depth, the Angle Lambda and the Fixation Disparity in Healthy Individuals

Acronym: EPOLAF

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Nov 14, 2022
Registry last updated
Sep 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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