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Completed

NCT Number: NCT04886219

Studies of the Angle Kappa and the Angle Alpha

Anatomical ophthalmological connections and their dynamics are still debated in the scientific community. However, their considering is essential in many surgeries (strabismus, cataract, refractive...) or in clinical practice.

The correlation between these biometric values would make it possible to refine the knowledge related to these landmarks and thus offer better ophthalmological management by integrating these variables into the clinical examination.

The aim of the study is to analyze the correlation between the angle alpha and the angle kappa in a healthy individual without ophthalmologic disorder.

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Key information

Conditions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hôpital Necker-Enfants Malades

Paris, 75015, France

About this study

The angle kappa corresponds to the angle formed between the visual axis (line between the point of fixation and the fovea: area of the retina allowing precise vision) and the pupillary axis (line passing through the center of the pupil and perpendicular to the cornea). The angle alpha corresponds to the angle formed between the visual axis and the optical axis (line passing through the nodal point of the eye and corneal center).

In theory, the angle kappa and angle alpha are equal; but physiological corectopy in the nasal position induces a variation between these two angles; the angle kappa being generally less than the angle alpha without a correlation being established. Also, pupillary constriction causes a variation in the position of the center of the pupil. The angle kappa therefore exhibits a variation depending on the expansion.

Anatomical ophthalmological connections and their dynamics are still debated in the scientific community. However, their considering is essential in many surgeries (strabismus, cataract, refractive ...) or in clinical practice.

The correlation between these biometric values would make it possible to refine the knowledge related to these landmarks and thus offer better ophthalmological management by integrating these variables into the clinical examination.

The aim of the study is to analyze the correlation between the angle alpha and the angle kappa in a healthy individual without an eye disorder.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Informed major subject not opposing to their participation in the study

Exclusion criteria

  • Subject with strabismus or organic ophthalmologic pathology

Treatment and study plan

Eye examination

Other
  • Multimodal fundus imaging (color fundus photography, optical coherence tomography (OCT))
  • orthoptic assessment (Visual acuity, Refraction, Cover test, Stereopsis evaluation
  • ocular biometry
  • corneal topography
  • monocular photographs in photopic and scotopic condition

Primary outcomes

  1. Value of the angle Kappa

    Time frame: Day 0

    Semi-automatic digital method of measurement by eye photography

  2. Value of the angle Alpha

    Time frame: Day 0

    Semi-automatic digital method of measurement by eye photography

Secondary outcomes

  1. Variation of the Kappa angle depending on the pupillary diameter

    Time frame: Day 0

    Variation in the same individual. Value of the Kappa angle using the semi-automatic method of measurement by ocular photography in photopic and scotopic conditions & measurement of the pupillary diameter using the photographs obtained

  2. Correlation between the value of the angle Alpha and the Optic disc / fovea distance

    Time frame: Day 0

    Angle Alpha value using the semi-automatic method of measurement by eye photography and the distance between the optic disc and the fovea

  3. Correlation between the angle Kappa and the axial length

    Time frame: Day 0

    Value of the angle Kappa and Alpha using the semi-automatic method of measurement by eye photography and Value of the axial length measured by biometry IolMaster 500 (Carl Zeiss)

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Collaborators

  • URC-CIC Paris Descartes Necker Cochin

Registry information

Official study title

Studies of the Characteristics of the Angle Kappa and the Angle Alpha in the Healthy Individual. Studies of the Angle Kappa and the Angle Alpha

Acronym: EKAPS

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
May 14, 2021
Registry last updated
Sep 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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