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Completed

NCT Number: NCT04442087

Study of Seroprevalence of Anti-SARS-CoV2 Among Children of Hospital Workers in AP-HP

The purpose of this study is to define seroprevalence of anti-SARS-CoV2 among children of Hospital Workers in APHP, particularly exposed population, according to parents' SARS-CoV2 serological status.

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Key information

Conditions

Sars-CoV2 COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre d'investigation clinique (CIC) Necker Cochin in Necker Children's Hospital

Paris, 75015, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Hospital workers :

  • Individuals aged over 18, having a professional activity at the APHP (employees, interns, volunteers)
  • Affiliated to a social security regimen
  • Have at least one child under the age of 18 living in the same house.
  • have signed consent

Child (ren), spouse and other member (s) residing at household:

Child (ren), spouse and any other member residing in the household of a professional of the Paris Center Hospitals meeting the inclusion criteria above.

Exclusion criteria

Refuse to participate in research

Treatment and study plan

Serology SARS-CoV2

Biological

Collect serum for Serology SARS-CoV2 at inclusion

Data collection

Behavioral

Collect clinical and demographic data, habitus, Lifestyle Counseling at inclusion

Primary outcomes

  1. Seroprevalence of antibodies anti- SARS Cov2 in blood sample of children of Hospital workers

    Time frame: at inclusion

    Percentage of children with seropositive in blood sample according to parents' SARS Cov2 serological status

  2. Seroprevalence of antibodies anti- SARS Cov2 in saliva sample of children of Hospital workers

    Time frame: at inclusion

    Percentage of children with seropositive according in saliva sample to parents' SARS Cov2 serological status

Secondary outcomes

  1. Number of Asymptomatic Children with a positive seroloy

    Time frame: At inclusion

  2. Number of severely symptomatic Children with a positive serology

    Time frame: At inclusion

  3. Prevalence of different clinical symptoms in children with a positive serology

    Time frame: At inclusion

  4. Serological result of each member of the family

    Time frame: At inclusion

  5. Number of spouses of hospital workers with a positive serology

    Time frame: At inclusion

  6. Number of Asymptomatic spouses of hospital workers with a positive serology

    Time frame: At inclusion

  7. Number of severely symptomatic spouses of hospital workers with a positive serology

    Time frame: At inclusion

  8. Comparison of Serological result obtained in blood and saliva samples

    Time frame: At inclusion

  9. Risk factors based on a questionnaire for children and adults

    Time frame: At inclusion

    the following factors will be of particular importance: characteristics and composition of the family home, barrier measures, medical history and comorbidities.

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Collaborators

  • URC-CIC Paris Descartes Necker Cochin

Registry information

Official study title

Seroprevalence of Anti-SARS-CoV2 Among Children According to Parents' SARS-CoV2 Serological Status. Study in a Hospital Population Assistance Publique-Hôpitaux Paris

Acronym: FamilyPEDCOVID

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Jun 22, 2020
Registry last updated
Nov 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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