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Completed

NCT Number: NCT04385810

Description of Ophthalmologic Injuries in Intensive Care During the SARS-CoV2 Epidemic - COVID19

The management of patients with SARS-CoV2 in respiratory distress can expose to corneal or retinal lesions induced by the stay in intensive care.

Examination by ophthalmologists would make it possible to detect the most of the ophthalmologic problems known in intensive care and to provide an early, preventive or curative therapeutic response when possible, in order to avoid irreversible visual loss.

The object of the research is to assess the presence and the importance of surface ophthalmologic lesions, the presence and the importance of retinal or optic nerve lesions, in order to improve the monitoring and primary prevention of this population

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Key information

Conditions

Covid19 COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Sars-CoV2 Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Fondation Adolphe de Rothschild

Paris, 75019, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient SARS-CoV2 positive (RT-PCR or chest scanner)
  • hospitalized in intensive care

Exclusion criteria

  • traumatic lesion of the face or any other condition preventing any ophthalmological evaluation

Treatment and study plan

Ophthalmologic exam

Procedure

Direct exam and Slit lamp exam Shirmer test Retinophotography At inclusion, day 7, day 14 and discharge from hospital

Primary outcomes

  1. Describe ophthalmologic damage to the cornea with direct exam at day 0

    Time frame: Day 0

    Direct exam

  2. Describe ophthalmologic damage to the cornea with direct exam at day 7

    Time frame: Day 7

    Direct exam

  3. Describe ophthalmologic damage to the cornea with direct exam at day 14

    Time frame: Day 14

    Direct exam

  4. Describe ophthalmologic damage to the cornea with direct exam at discharge of hospital

    Time frame: Discharge of hospital, up to 3 months

    Direct exam

  5. Describe ophthalmologic damage to the cornea with slit lamp exam at day 0

    Time frame: Day 0

    Slit lamp exam

  6. Describe ophthalmologic damage to the cornea with slit lamp exam at day 7

    Time frame: Day 7

    Slit lamp exam

  7. Describe ophthalmologic damage to the cornea with slit lamp exam at day 14

    Time frame: Day 14

    Slit lamp exam

  8. Describe ophthalmologic damage to the cornea with slit lamp exam at discharge of hospital

    Time frame: Discharge of hospital, up to 3 months

    Slit lamp exam

  9. Describe tear film anomalies at day 0

    Time frame: Day 0

    Shirmer test

  10. Describe tear film anomalies at day 7

    Time frame: Day 7

    Shirmer test

  11. Describe tear film anomalies at day 14

    Time frame: Day 14

    Shirmer test

  12. Describe tear film anomalies at discharge of hospital

    Time frame: Discharge of hospital, up to 3 months

    Shirmer test

  13. Describe ophthalmologic damage to the retina at day 0

    Time frame: Day 0

    Retinophotography

  14. Describe ophthalmologic damage to the retina at day 7

    Time frame: Day 7

    Retinophotography

  15. Describe ophthalmologic damage to the retina at day 14

    Time frame: Day 14

    Retinophotography

  16. Describe ophthalmologic damage to the retina at discharge of hospital

    Time frame: Discharge of hospital, up to 3 months

    Retinophotography

  17. Describe ophthalmologic damage to the optic nerve at day 0

    Time frame: Day 0

    Retinophotography

  18. Describe ophthalmologic damage to the optic nerve at day 7

    Time frame: Day 7

    Retinophotography

  19. Describe ophthalmologic damage to the optic nerve at day 14

    Time frame: Day 14

    Retinophotography

  20. Describe ophthalmologic damage to the optic nerve at discharge of hospital

    Time frame: Discharge of hospital, up to 3 months

    Retinophotography

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: DOCOV

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
May 13, 2020
Registry last updated
Jan 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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