Study of JMKX003948 Ophthalmic Suspension in Healthy Participants

Inclusion criteria

• Healthy adult males and/or females, 18 to 45 years of age (inclusive) at the date of signed consent form.
• Body mass index (BMI) greater than or equal to 18 and less than 32 (kg/m2) and a minimum body weight of 45 kg.
• Able to participate and comply with all study procedures and restrictions, and willing to provide written informed consent to participate in the study.
• Women of child-bearing potential and sexually active males willing to use highly effective methods of contraception from screening until 3 months after last dose of study drug. In addition, participants must not donate sperm/egg for the time period specified above.

Exclusion criteria

• History of disease of ocular surface, fundus, central nervous system, psychiatric and psychological condition, cardiovascular system, kidney, liver, digestive system, respiratory system, or metabolic/endocrine system, or other disease that in the opinion of the Investigator (or medically qualified designee) may make participation unsafe for the participant or interfere with study evaluations.
• Any abnormal examination with clinical significance may interfere with study evaluations in opinion of the Investigator (or medically qualified designee).
• History of eye trauma or surgery including LASIK/LASEK.
• Any corrected visual acuity < 20/20, or intraocular pressure ≥ 21 mmHg.
• Clinically significant abnormalities on ophthalmic examination that would hinder the assessment of the eye or data collection at the discretion of the Investigator and/or ophthalmologist (or medically qualified designee).