Recruiting

NCT Number: NCT03346772

Study of Immune Responses to Influenza Vaccination

Better understanding of the immune responses to influenza vaccination is needed in order to understand situations of poor vaccine response. Adults will receive influenza vaccination and then have peripheral blood drawn at pre-defined intervals in order to study the lymphocyte responses.

Recruiting

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Key information

Conditions

Influenza Vaccination Infections Influenza, Human Orthomyxoviridae Infections RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location status: Recruiting

Location contact

E. John Wherry, PhD

PRINCIPAL_INVESTIGATOR

Sokratis Apostolidis, MD

CONTACT

[email protected]

267-584-6653

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Community-dwelling adults able to provide consent who need influenza vaccination for standard of care

Exclusion criteria

febrile illness at time of vaccination
active malignancy
use of immunosuppressing medications
blood donation in the past 60 days
influenza vaccinated during the preceding 6 months
allergic reactions to influenza vaccination

Treatment and study plan

Influenza vaccination

Biological

Adults will receive one intramuscular dose of seasonal quadrivalent inactivated influenza vaccine, as indicated for standard of care.

Primary outcomes

Influenza neutralizing antibody titers

Time frame: 21-42 days

Study contacts

Contact information is provided by the study sponsor or research team.

E.John Wherry, PhD

CONTACT

[email protected]

Sokratis Apostolidis, MD

CONTACT

[email protected]

267-584-6653

Sponsors and collaborators

Lead sponsor

University of Pennsylvania

Other

Registry information

Important dates

Study start: 2017
Primary completion: 2026
Study completion: 2026
First posted: Nov 17, 2017
Registry last updated: Aug 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Recruiting