Study of Histological Samples From Patients With Hereditary Haemorrhagic Telangiectasia

In this study the investigators will obtain histological samples from people with hereditary haemorrhagic telangiectasia (HHT, also known as Osler-Weber-Rendu Syndrome).

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Key information

Conditions

Telangiectasia, Hereditary Hemorrhagic Cardiovascular Abnormalities Cardiovascular Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Hematologic Diseases Hemic and Lymphatic Diseases Hemorrhagic Disorders Hemostatic Disorders Telangiectasis Vascular Diseases Vascular Malformations

Sex eligibility

All sexes

Study type

Observational

Primary location

Imperial College Hammersmith Campus

London, W12 0NN, United Kingdom

About this study

HHT is an inherited condition that leads to the development of dilated and fragile blood vessels. We propose to obtain small skin samples from patients with HHT in order to analyze the samples using histological methods, and study the properties of vascular endothelial cells derived from patients. We hypothesize that these cells will show differences when compared to normal endothelial cells, which may be confirmed in single time point analyses in histological samples. We anticipate that that these findings may help to explain aspects of the HHT disease phenotype.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with Hereditary Haemorrhagic Telangiectasia

Exclusion criteria

Unable to provide informed consent

Sponsors and collaborators

Lead sponsor

Imperial College London

Other

Registry information

Official study title

Histological Samples From Patients With Hereditary Haemorrhagic Telangiectasia

Important dates

Study start: 2008
Primary completion: 2016
Study completion: 2016
First posted: Aug 13, 2008
Registry last updated: Sep 28, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed