Study of Heat and Intravenous Fluids for Exogenous Rewarming

The purpose of this study is to compare two novel active rewarming techniques in mildly hypothermic people. Volunteers will undergo 3 cooling trials in a circulating bath at 14 degrees celsius and will then be rewarmed with either shivering alone, warmed iv fluids (IVF), or water perfusion pads applied to the hands and feet. The investigators hypothesize that both heated IVF and water perfusion pads to the arteriovenous anastomoses (AVAs) will prove to provide significantly superior rewarming rates than shivering alone.

Completed

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Key information

Conditions

Hypothermia Arteriovenous Fistula Arteriovenous Malformations Body Temperature Changes Cardiovascular Abnormalities Cardiovascular Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Fistula Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms Vascular Diseases Vascular Fistula Vascular Malformations

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Any healthy male or female over 18 years of age

Exclusion criteria

No heart/blood pressure/cholesterol medications.
No history of Raynaud's disease or any other condition (including asthma) that could be aggravated by cold-water immersion

Treatment and study plan

Warmed IV fluids

Other

1 Liter of warmed IV fluids at 42 degrees celsius

Warmed perfusion pads

Other

Neoprene perfusion pads placed on the palms and soles to rewarm through focusing on the arteriovenous anastomoses

Primary outcomes

Rate of rewarming

Time frame: 60 minutes

Track to rate of rewarming of each arm

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Official study title

Study of Heat and Intravenous Fluids for Exogenous Rewarming (SHIVER)

Acronym: SHIVER

Important dates

Study start: 2015
Primary completion: 2015
Study completion: 2015
First posted: Jan 15, 2015
Registry last updated: Nov 26, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed