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Completed

NCT Number: NCT01075061

Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification PROJET " MOMIC "

Mirror movements are involuntary, symmetrical and simultaneous movements occurring on one side of the body that accompany controlateral voluntary movements. Congenital mirror movements (CMM) are characterized by childhood onset and the absence of additional manifestations. The aim of this study is to unravel the pathophysiology of the CMM that remains poorly elucidated. The combination of imaging studies and neurophysiological studies using transcranial magnetic stimulation in a homogeneous and relatively large group of patient is likely to allow us to better understand the underlying pathophysiology of the disorder. Using a linkage analysis approach we will try to identify a locus associated with CMM and related candidate genes.

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Key information

Conditions

Healthy

Age range

11 year–82 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Fédération des Maladies du Système Nerveux, Hôpital Pitié Salpétrière

Paris, 75013, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged from 11 to 82 years
  • Members of the family of interest displaying mirror movements or being obligatory asymptomatic carrier, without additional manifestation or malformation; or patient with genetically proven Kallmann syndrome and mirror movements.
  • No contraindication for MRI or TMS study

Exclusion criteria

  • inability to provide an informed consent
  • Simultaneous participation in another clinical trial
  • Treatment that modulate cortical excitability (for the TMS part of the study only)

Treatment and study plan

Healthy Volunteers

Other

morphological and functional brain MRI; transcranial magnetic stimulation

Kallmann

Other

morphological and functional brain MRI; transcranial magnetic stimulation

Congenital Mirror Movement

Other

morphological and functional brain MRI; transcranial magnetic stimulation

Primary outcomes

  1. - To unravel the pathophysiology of congenital mirror movements - To identify a locus and candidate genes associated with CMM

    Time frame: 08/2011

Secondary outcomes

  1. - To study patients with Kallmann syndrome and associated MM based on the same methods and hypothesis

    Time frame: 08/2011

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Registry information

Official study title

Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification : MOMIC

Acronym: MOMIC

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Feb 24, 2010
Registry last updated
Aug 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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