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NCT Number: NCT07239388

Structured Group Therapy in Reducing Depression and Anxiety in Pakistan

This study aims to assess the effectiveness of Cognitive Behavioural Therapy (CBT) and Mindfulness-Based Stress Reduction (MBSR) in group settings to reduce symptoms of depression and anxiety, enhance emotional resilience, and improve social support among Pakistani individuals struggling with these conditions.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Mental health disorders, particularly depression and anxiety, are prevalent in Pakistan and significantly affect the emotional, social, and occupational well-being of individuals. According to the World Health Organisation (WHO), depression is the leading cause of disability globally, and anxiety disorders are among the most common mental health conditions in Pakistan, affecting millions.

In the Pakistani context, stigma surrounding mental illness, lack of awareness, and limited access to mental health services create substantial barriers to care. Group therapy, which provides a collective support system and skill-building strategies, can be an effective modality in addressing these challenges. Structured group therapy offers participants a sense of community, reduces feelings of isolation, and provides a platform for learning coping strategies within a culturally sensitive framework.

This study aims to assess the effectiveness of Cognitive Behavioural Therapy (CBT) and Mindfulness-Based Stress Reduction (MBSR) in group settings to reduce symptoms of depression and anxiety, enhance emotional resilience, and improve social support among Pakistani individuals struggling with these conditions.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults (18-65 years)
  • Diagnosed with moderate to severe depression
  • Residing in urban or rural areas of Pakistan
  • Willingness to attend 12 weekly group therapy sessions and comply with the study protocol

Exclusion criteria

  • Severe psychiatric disorders (e.g., psychosis, bipolar disorder)
  • Ongoing substance abuse or severe substance use disorder
  • Participation in other therapeutic interventions (e.g., individual therapy or group therapy) during the study period
  • Cognitive impairments that would interfere with participation

Treatment and study plan

Structured group therapy

Other

Participants will receive Cognitive Behavioural Therapy (CBT) and Mindfulness-Based Stress Reduction (MBSR) therapy techniques in group settings. The intervention will cover contents like: (1) Introduction to Depression and Anxiety: Understanding symptoms and causes; (2) Cognitive Restructuring: Identifying and challenging negative thoughts; (3) Stress Management: Techniques for managing physiological and psychological stress; (4) Mindfulness Practices: Meditation, breathing exercises, and body scanning; (5) Behavioural Activation: Planning and engaging in pleasurable and meaningful activities; (6) Social Support: Building and enhancing relationships; (7) Relapse Prevention: Strategies for maintaining progress after the intervention.

Each group will consist of 8-10 participants to allow for optimal interaction and support. Twelve weekly group sessions, each lasting 90 minutes, will be conducted.

Primary outcomes

  1. Depression and anxiety

    Time frame: 12 weeks

    As measured through the participants' scores on the Hospital Anxiety & Depression Scale (HADS)

Secondary outcomes

  1. Social support

    Time frame: 12 weeks

    As measured through participants' scores on the Multidimensional Scale of Perceived Social Support (MSPSS)

  2. Functionality of participants

    Time frame: 12 weeks

    As measured through participants' scores on the WHO Disability Assessment Schedule (WHODAS 2.0)

Sponsors and collaborators

Lead sponsor

Pakistan Association of Cognitive Therapists

Other

Registry information

Official study title

Effectiveness of Structured Group Therapy in Reducing Depression and Anxiety Symptoms in Pakistan: A Randomised Controlled Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Nov 20, 2025
Registry last updated
Nov 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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