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OpenTrials
Completed

NCT Number: NCT00916682

Structure and Function of Salivary Proteins

This study seeks to provide point-of-care clinical diagnostic systems for the diagnosis of current disease status using saliva as a sample specimen.

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Key information

Conditions

Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities Digestive System Diseases Genetic Diseases, Inborn Infant, Newborn, Diseases Lung Diseases Pancreatic Diseases Respiratory Tract Diseases

Age range

6 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Children's Hosptital, Boston

Boston, Massachusetts, 02115, United States

About this study

The overall hypothesis of this study is that whole saliva and its components, due to its direct anatomic relation to the airways, provides a window on the composition and nature of the disease-specific response in the bronchial, sinus, and nasal airways. By examining proteins created in saliva, we hope to validate that saliva is an important diagnostic tool for for rapid analysis of respiratory status. We further propose that rapid salivary diagnostics will improve patient care in prevalent respiratory diseases with frequent health care utilization and high morbidity, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 6 or more years of age
  • confirmed Cystic Fibrosis

Exclusion criteria

  • Pregnant

Treatment and study plan

Primary outcomes

  1. Salivary Biomarkers

    Time frame: Baseline

    Biomarkers of inflammation in saliva

Sponsors and collaborators

Lead sponsor

Boston Children's Hospital

Other

Collaborators

  • Ahura Scientific, Inc.
  • Boston Medical Center
  • Boston University
  • Tufts University
  • University of North Carolina, Chapel Hill

Registry information

Important dates

Study start
2007
Primary completion
2013
Study completion
2013
First posted
Jun 9, 2009
Registry last updated
Jun 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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